Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, China.
Department of Gastroenterology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.
J Dig Dis. 2023 Nov;24(11):572-583. doi: 10.1111/1751-2980.13233. Epub 2023 Nov 14.
The incidence and prevalence of inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn's disease (CD), are increasing globally. We aimed to evaluate the potential association between IBD and nephrolithiasis, tubulointerstitial nephritis, and chronic kidney disease (CKD).
Data of hospitalized adults ≥20 years of age were extracted from the U.S. National Inpatient Sample (NIS) during 2016-2018. Patients with UC, CD, or CKD were identified through the International Classification of Diseases, Tenth Revision (ICD-10) codes. Propensity score matching (PSM) analysis (1:1) was conducted to balance the characteristics between groups. Logistic regression analyses were performed to determine the relationships between UC or CD and kidney conditions.
Three cohorts were included for analysis after PSM analysis. Cohorts 1, 2 and 3 contained 235 262 subjects (117 631 with CD or without IBD), 140 856 subjects (70 428 with UC or without IBD), and 139 098 subjects (69 549 with CD or UC), respectively. Multivariate analysis revealed that compared to non-IBD individuals, CD patients were significantly associated with greater odds for nephrolithiasis (adjusted odds ratio [aOR] 2.25, 95% confidence interval [CI] 2.08-2.43), tubulointerstitial nephritis (aOR 1.31, 95% CI 1.24-1.38), CKD at any stage (aOR 1.28, 95% CI 1.24-1.32), and moderate-to-severe CKD (aOR 1.22, 95% CI 1.17-1.26), while UC was associated with a higher rate of nephrolithiasis. Compared to UC, CD was associated with higher odds for all such kidney conditions.
Patients with CD are more likely to have nephrolithiasis, tubulointerstitial nephritis, CKD at any stage, and moderate-to-severe CKD compared to non-IBD individuals.
炎症性肠病（IBD）的发病率和患病率呈全球上升趋势，主要包括溃疡性结肠炎（UC）和克罗恩病（CD）。本研究旨在评估 IBD 与肾结石、肾小管间质性肾炎和慢性肾脏病（CKD）之间的潜在关联。
从 2016 年至 2018 年美国国家住院患者样本（NIS）中提取 20 岁以上成年人的住院数据。通过国际疾病分类，第 10 次修订版（ICD-10）代码识别 UC、CD 或 CKD 患者。采用倾向评分匹配（PSM）分析（1:1）平衡组间特征。采用 logistic 回归分析确定 UC 或 CD 与肾脏疾病的关系。
PSM 分析后纳入三个队列进行分析。队列 1、2 和 3 分别包含 235262 例患者（117631 例合并 CD 或不合并 IBD）、140856 例患者（70428 例合并 UC 或不合并 IBD）和 139098 例患者（69549 例合并 CD 或 UC）。多变量分析显示，与非 IBD 个体相比，CD 患者肾结石（校正比值比[aOR]2.25，95%置信区间[CI]2.08-2.43）、肾小管间质性肾炎（aOR 1.31，95%CI 1.24-1.38）、任何阶段 CKD（aOR 1.28，95%CI 1.24-1.32）和中重度 CKD（aOR 1.22，95%CI 1.17-1.26）的发生风险显著更高，而 UC 与肾结石的发生率更高相关。与 UC 相比，CD 与所有这些肾脏疾病的发生风险更高相关。
与非 IBD 个体相比，CD 患者肾结石、肾小管间质性肾炎、任何阶段 CKD 和中重度 CKD 的发生风险更高。
