Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
Department of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195, Berlin, Germany.
Angew Chem Int Ed Engl. 2023 Nov 20;62(47):e202310357. doi: 10.1002/anie.202310357. Epub 2023 Oct 25.
Peptides and nucleic acids with programmable sequences are widely explored for the production of tunable, self-assembling functional materials. Herein we demonstrate that the primary sequence of oligosaccharides can be designed to access materials with tunable shapes and properties. Synthetic cellulose-based oligomers were assembled into 2D or 3D rod-like crystallites. Sequence modifications within the oligosaccharide core influenced the molecular packing and led to the formation of square-like assemblies based on the rare cellulose IV allomorph. In contrast, modifications at the termini generated elongated aggregates with tunable surfaces, resulting in self-healing supramolecular hydrogels.
具有可编程序列的肽和核酸被广泛探索用于生产可调谐、自组装的功能材料。在此，我们证明了寡糖的一级序列可以被设计用来获得具有可调形状和性能的材料。基于纤维素的合成寡聚物被组装成 2D 或 3D 棒状结晶。寡糖核心内的序列修饰影响分子堆积，导致基于罕见纤维素 IV 变体的方形组装体的形成。相比之下，在末端进行修饰会产生具有可调表面的伸长聚集体，从而形成自修复超分子水凝胶。
