Jelic Marija, Mandic Aljosa, Maricic Slobodan, Bozin Biljana, Kladar Nebojsa, Sudji Jan, Conic Branislava Srdjenovic
University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Oncology Institute of Vojvodina, Sremska Kamenica, Serbia.
Exp Oncol. 2023 Oct 11;45(2):231-241. doi: 10.15407/exp-oncology.2023.02.231.
The aim of our study was to measure the levels of 8-hydroxy-2-deoxyguanosine, malondialdehyde, and antioxidant enzymes in patients with locally advanced cervical cancer prior to treatment to determine how these evaluated biomarkers are associated with cervical cancer recurrence and to estimate their potential in further research and clinical use.
The study included 45 female patients with newly diagnosed advanced cervical cancer who underwent concomitant chemoradiotherapy. The blood and urine samples were collected prior to treatment, between December 2013 and April 2016, and subsequent laboratory analysis was performed. After the medium follow-up of 29 months, the patients were divided into 3 groups according to the time of disease recurrence. A statistical analysis was performed in order to evaluate the relationship between the previously measured biomarkers and recurrence.
Taken individually, the parameters of oxidative stress did not reveal significant differences between the three groups in our study. Nevertheless, the catalase and glutathione S-transferase activities were the best predictors of the recurrence. Based on the activities of these two oxidative enzymes, it was possible to separate the group of patients without recurrence after follow-up from the other two groups of patients with recurrent disease.
The parameters of oxidative stress have a certain predictive value on the outcome of patients with advanced cervical cancer after concomitant chemo-radiotherapy.
我们研究的目的是测量局部晚期宫颈癌患者治疗前8-羟基-2-脱氧鸟苷、丙二醛和抗氧化酶的水平，以确定这些评估的生物标志物与宫颈癌复发的关联，并评估它们在进一步研究和临床应用中的潜力。
该研究纳入了45例新诊断为晚期宫颈癌并接受同步放化疗的女性患者。在2013年12月至2016年4月期间，于治疗前采集血液和尿液样本，并进行后续实验室分析。经过29个月的中位随访后，根据疾病复发时间将患者分为3组。进行统计分析以评估先前测量的生物标志物与复发之间的关系。
单独来看，氧化应激参数在我们的研究中三组之间未显示出显著差异。然而，过氧化氢酶和谷胱甘肽S-转移酶活性是复发的最佳预测指标。基于这两种氧化酶的活性，可以将随访后无复发的患者组与其他两组复发疾病患者区分开来。
氧化应激参数对同步放化疗后晚期宫颈癌患者的预后具有一定的预测价值。
