Kaulen D R, Snegireva A E, Khorobrykh V V, Shevliagin V Ia, Prigoda O S
Biull Eksp Biol Med. 1979 May;87(5):438-41.
It was shown that mouse antiserum against isologous thermically aggregated immunoglobulins MAAS injected repeatedly to the animals prolonged the survival of the skin allotransplant, induced Moloney's sarcoma diminished the latent period of the tumour development sharply increased the formation of the tumours which in the majority of cases, led to the death of mice, deranged the normal age barrier in fibrosarcoma induction, and sharply inhibited the intensity of Rauscher's leukemia development. This action of MAAS on the transplantation and antitumour immunity was of immunological nature.
结果表明，将抗同源热聚集免疫球蛋白的小鼠抗血清（MAAS）反复注射给动物，可延长皮肤同种异体移植的存活时间，诱发莫洛尼氏肉瘤，显著缩短肿瘤发展的潜伏期，大幅增加肿瘤的形成，在大多数情况下导致小鼠死亡，扰乱纤维肉瘤诱导中的正常年龄屏障，并显著抑制劳舍尔白血病的发展强度。MAAS对移植和抗肿瘤免疫的这种作用具有免疫性质。
