Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Facultad de Ciencias Biológicas, Departamento de Inmunología y Virología, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico.
Genesis. 2024 Feb;62(1):e23561. doi: 10.1002/dvg.23561. Epub 2023 Oct 13.
Hox genes encode transcription factors that play an important role in establishing the basic body plan of animals. In Drosophila, Antennapedia is one of the five genes that make up the Antennapedia complex (ANT-C). Antennapedia determines the identity of the second thoracic segment, known as the mesothorax. Misexpression of Antennapedia at different developmental stages changes the identity of the mesothorax, including the muscles, nervous system, and cuticle. In Drosophila, Antennapedia has two distinct promoters highly regulated throughout development by several transcription factors. Antennapedia proteins are found with other transcription factors in different ANTENNAPEDIA transcriptional complexes to regulate multiple subsets of target genes. In this review, we describe the different mechanisms that regulate the expression and function of Antennapedia and the role of this Hox gene in the development of Drosophila.
Hox 基因编码转录因子，在建立动物的基本身体蓝图中发挥着重要作用。在果蝇中，触角足畸形（Antennapedia）是构成触角足畸形复合体（ANT-C）的五个基因之一。触角足畸形决定了第二个胸节的身份，即中胸。在不同的发育阶段异位表达触角足畸形会改变中胸的身份，包括肌肉、神经系统和外骨骼。在果蝇中，触角足畸形有两个不同的启动子，在发育过程中受到几个转录因子的高度调控。触角足畸形蛋白与其他转录因子一起存在于不同的触角足畸形转录复合物中，以调节多个目标基因的亚群。在这篇综述中，我们描述了调控触角足畸形表达和功能的不同机制，以及这个 Hox 基因在果蝇发育中的作用。
