Braillon A, Lee S S, Girod C, Peignoux-Martinot M, Valla D, Lebrec D
J Lab Clin Med. 1986 Dec;108(6):543-8.
We evaluated the role of portasystemic shunts in the hyperkinetic circulatory state in rats with portal hypertension. Cardiac output and regional blood flow were measured by the radioactive microsphere technique in rats with portal hypertension caused by portal vein stenosis, in rats with end-to-side portacaval shunts, and in sham-operated rats. Cardiac output was significantly higher in rats with surgical shunts than in those of the two other groups and was significantly lower in sham-operated rats compared with portal hypertensive rats. Portal tributary blood flow and hepatic arterial blood flow expressed in absolute flow as well as in percentage of cardiac output were significantly increased in rats with surgical shunts compared with other groups. These blood flows were also significantly higher in portal hypertensive rats than in sham-operated animals. A significant correlation was found between cardiac output and portal tributary blood flow in rats with portal vein stenosis and in rats with surgical shunts; this correlation was absent in sham-operated rats. This study shows that the hyperkinetic circulatory state in rats with portal hypertension and a normal liver is related to the presence of portasystemic shunts but not to portal hypertension per se.
我们评估了门体分流在门静脉高压大鼠高动力循环状态中的作用。采用放射性微球技术，对门静脉狭窄所致门静脉高压大鼠、端侧门腔分流大鼠及假手术大鼠的心输出量和局部血流进行了测量。手术分流大鼠的心输出量显著高于其他两组，且假手术大鼠的心输出量显著低于门静脉高压大鼠。与其他组相比，手术分流大鼠门静脉分支血流和肝动脉血流的绝对流量以及占心输出量的百分比均显著增加。门静脉高压大鼠的这些血流也显著高于假手术动物。在门静脉狭窄大鼠和手术分流大鼠中，心输出量与门静脉分支血流之间存在显著相关性；而在假手术大鼠中不存在这种相关性。本研究表明，门静脉高压且肝脏正常的大鼠的高动力循环状态与门体分流的存在有关，而与门静脉高压本身无关。
