School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Bearsden, Glasgow G61 1QH, U.K.
Oncology, Philips Research Eindhoven, High Tech Campus 34, 5656 AE Eindhoven, The Netherlands.
Biochem J. 2023 Oct 31;480(20):1599-1614. doi: 10.1042/BCJ20230297.
Prostate cancer is one of the most common cancers in men and one of the top causes of death in men worldwide. Development and function of both normal prostate cells and early-stage prostate cancer cells are dependent on the cross-talk between androgen signalling systems and a variety of other transduction pathways which drive differentiation of these cells towards castration-resistance. One such signalling pathway is the ubiquitous cAMP signalling axis which functions to activate spatially restricted pools of cAMP effectors such as protein kinase A (PKA). The importance of both PKA and cAMP in the development of prostate cancer, and their interactions with the androgen receptor, were the focus of a review by Merkle and Hoffmann in 2010. In this updated review, we revisit this topic with analysis of current PKA-related prostate cancer literature and introduce novel information on the relevance of another cAMP effector, the exchange protein directly activated by cAMP (EPAC).
前列腺癌是男性最常见的癌症之一，也是全球男性死亡的主要原因之一。正常前列腺细胞和早期前列腺癌细胞的发育和功能都依赖于雄激素信号系统与各种其他转导途径之间的相互作用，这些途径促使这些细胞向去势抵抗分化。这样的信号通路之一是普遍存在的 cAMP 信号轴，它的功能是激活 cAMP 效应物（如蛋白激酶 A（PKA））的空间限制池。PKA 和 cAMP 在前列腺癌发展中的重要性，以及它们与雄激素受体的相互作用，是 Merkle 和 Hoffmann 在 2010 年的一篇综述的重点。在这篇更新的综述中，我们通过分析当前与 PKA 相关的前列腺癌文献，重新探讨了这一主题，并介绍了另一种 cAMP 效应物——cAMP 直接激活的交换蛋白（EPAC）的相关性的新信息。
