Genomic, transcriptomic, and phenotypic differences among archetype strains of serotypes 2a, 3a, and 6.

Given the genomic diversity between serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied and functional analyses of archetype strains of 2457T (2a), J17B (3a), and CH060 (6). These archetype strains represent the three leading serotypes recommended for inclusion in multivalent vaccines. Characterizing the genomic and phenotypic variation among these clinically prevalent serotypes is an important step toward understanding serotype-specific host-pathogen interactions to optimize the efficacy of multivalent vaccines and therapeutics. This study underpins the importance for further large-scale serotype-targeted analyses.