Department of Dermatology, Essen University Hospital, Essen, Germany.
Convatec, Deeside, Flintshire, UK.
J Wound Care. 2023 Oct 2;32(10):624-633. doi: 10.12968/jowc.2023.32.10.624.
To compare Aquacel Ag Advantage/Ag+ Extra (Aquacel Ag+) (Convatec, UK) and Cutimed Sorbact (Sorbact) (Essity, US) dressings indicated for the treatment of patients with venous leg ulcers (VLUs), diabetes foot ulcers (DFUs) and pressure injuries (PIs) for clinical performance and outcomes using real-world evidence in Germany and the US.
This study was a chart audit review of patients who used either Aquacel Ag+ or Sorbact dressings in the 24 months prior to October 2022. Healthcare providers with access to electronic medical records and charts were asked to capture data via patient record forms. The quantitative data were analysed.
Findings in Germany were comparable between Aquacel Ag+ and Sorbact with regards to wound description, management and treatment outcomes, including percent area reduction and wound closure. A difference was that a greater proportion of Sorbact patients required surgery (0% versus 11%; p=0.039). In the US, a greater proportion of wounds were worsening before dressing in the Aquacel Ag+ cohort (49% versus 34%; p=0.010). A multinomial logistic regression yielded the result that patients who received Aquacel Ag+ were 3.53 times more likely to have the wound completely healed (p=0.033).
Both Aquacel Ag+ and Sorbact dressings are widely used in Germany and the US for patients with VLUs, DFUs and PIs. Our study found two important differences: patients who used Aquacel Ag+ were less likely to need further surgery in Germany; and in the US, there were significantly higher odds that wounds would completely heal with Aquacel Ag+ dressings compared to Sorbact.
使用真实世界证据比较英国康维特公司的 Aquacel Ag Advantage/Ag+ Extra（Aquacel Ag+）和美国爱惜康公司的 Cutimed Sorbact（Sorbact）两款敷料在德国和美国治疗静脉溃疡（venous leg ulcers，VLU）、糖尿病足溃疡（diabetes foot ulcers，DFU）和压力性损伤（pressure injuries，PI）患者的临床疗效和结局。
本研究为回顾性图表审查，纳入 2022 年 10 月前 24 个月内使用 Aquacel Ag+或 Sorbact 敷料的患者。有电子病历和图表查阅权限的医护人员被要求通过患者记录表采集数据。对定量数据进行分析。
德国的研究结果显示，Aquacel Ag+和 Sorbact 在伤口描述、管理和治疗结局方面相似，包括面积减少百分比和伤口愈合。有一个差异是 Sorbact 组中更多患者需要手术（0%比 11%；p=0.039）。在美国，Aquacel Ag+组在使用敷料前，更多伤口恶化（49%比 34%；p=0.010）。多变量逻辑回归结果显示，使用 Aquacel Ag+的患者完全愈合的可能性是使用 Sorbact 的 3.53 倍（p=0.033）。
Aquacel Ag+和 Sorbact 敷料在德国和美国均广泛用于 VLU、DFU 和 PI 患者。我们的研究发现两个重要差异：在德国，使用 Aquacel Ag+的患者不太可能需要进一步手术；在美国，Aquacel Ag+组完全愈合的可能性显著高于 Sorbact 组。
