Zeymer Uwe, Pöss Janine, Zahn Ralf, Thiele Holger
Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland.
Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Deutschland.
Herz. 2023 Dec;48(6):456-461. doi: 10.1007/s00059-023-05214-1. Epub 2023 Oct 13.
Out-of-hospital cardiac arrest (OHCA) is one of the most frequent causes of death in Europe and is associated with a dismal prognosis. The annual incidence in Germany is approximately 100-120 per 100,000 inhabitants (ca. 80,000-100,000 cases). With the use of cardiopulmonary resuscitation (CPR) about 40% of patients have a return of spontaneous circulation (ROSC); however, after OHCA only 15% of patients survive for 30 days and less than 10% survive with no or only minor neurological deficits. Data from the German Resuscitation Register demonstrate that there was no change in the results over the last 15 years, despite all medical innovations, higher rates of coronary interventions, higher use of mechanical support systems and improvement in intensive care treatment. A high proportion of patients with OHCA have a cardiac or coronary cause. As shown by the data from the German Cardiac Arrest Register (G-CAR) an early coronary angiography is often carried out after CPR in Germany; however, in randomized clinical studies an immediate coronary angiography in patients with non-ST segment elevation in the electrocardiogram (ECG) was not associated with an improvement in the prognosis. In large randomized studies the use of mechanical CPR systems and the implantation of mechanical circulatory support devices after OHCA also did not lead to a reduction in mortality. The most important impact factor for the success of CPR is the time interval between collapse and start of CPR, if possible also by bystander resuscitation. Therefore, the focus of efforts for improving CPR should be on increasing the rate of patients with early CPR. Experiences from Denmark and The Netherlands indicate that this can be successful by education and training of the general population, telephone resuscitation and apps for alerting lay persons.
院外心脏骤停(OHCA)是欧洲最常见的死亡原因之一,且预后不佳。德国的年发病率约为每10万居民100 - 120例(约80,000 - 100,000例)。通过实施心肺复苏(CPR),约40%的患者实现自主循环恢复(ROSC);然而,院外心脏骤停后只有15%的患者能存活30天,且存活时无或仅有轻微神经功能缺损的患者不到10%。德国复苏登记处的数据表明,尽管有所有的医学创新、更高的冠状动脉介入率、更多地使用机械支持系统以及重症监护治疗的改善,但在过去15年里结果并无变化。院外心脏骤停患者中很大一部分有心脏或冠状动脉病因。德国心脏骤停登记处(G - CAR)的数据显示,在德国,心肺复苏后常进行早期冠状动脉造影;然而,在随机临床研究中,心电图(ECG)无ST段抬高的患者立即进行冠状动脉造影与预后改善无关。在大型随机研究中,院外心脏骤停后使用机械心肺复苏系统和植入机械循环支持装置也未导致死亡率降低。心肺复苏成功的最重要影响因素是心脏骤停与开始心肺复苏之间的时间间隔,如有可能,也包括旁观者进行的复苏。因此,改善心肺复苏的工作重点应是提高早期接受心肺复苏患者的比例。丹麦和荷兰的经验表明,通过对普通民众进行教育和培训、电话复苏以及用于提醒非专业人员的应用程序,这一点可以实现。