中心性浆液性脉络膜视网膜病变中视网膜下液持续时间和基线脉络膜视网膜结构与光相干断层扫描的相关性。

Association of Subretinal Fluid Duration and Baseline Chorioretinal Structure With Optical Coherence Tomography in Central Serous Chorioretinopathy.

机构信息

Department of Ophthalmology, Shinseikai Toyama Hospital, Imizu, Japan.

Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan.

出版信息

Transl Vis Sci Technol. 2023 Oct 3;12(10):12. doi: 10.1167/tvst.12.10.12.

DOI:10.1167/tvst.12.10.12

PMID:37831445

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10587855/

Abstract

PURPOSE

This study investigated the association between subretinal fluid (SRF) duration and baseline chorioretinal structure in patients with naïve (first-episode and untreated) central serous chorioretinopathy (CSC).

METHODS

We divided 59 patients into non-prolonged (<3 months) and prolonged (>3 months) groups based on SRF fluid persistence from the initial visit. The follow-up period varied as the shorter duration was chosen between SRF disappearance time and 3 months from the initial visit. We measured the central retinal thickness (CRT), central choroidal thickness (CCT), SRF height (SRFH), and outer nuclear layer thickness (ONL) using spectral-domain optical coherence tomography (SD-OCT) at the initial visit and recorded SRF duration. We compared these parameters between the groups, conducted multivariate analysis for SRF duration of more than 3 months, and investigated the correlation among CCT and CRT, SRFH, or ONL, and among SRF duration and CRT, CCT, SRFH, or ONL.

RESULTS

CCT was significantly thicker in the prolonged than in the non-prolonged group at the initial visit (P = 0.044) and significantly correlated with CRT and SRFH (P = 0.007, r = 0.35 and P = 0.002, r = 0.39). SRF duration significantly correlated with CRT and SRFH (P = 0.009, r = 0.40 and P = 0.003, r = 0.41). The optimal model for SRF duration more than 3 months included age (P = 0.054) and CCT (P = 0.008).

CONCLUSIONS

Thicker baseline CCT can lead to a longer SRF duration in naïve CSC.

TRANSLATIONAL RELEVANCE

This association aids in early detection of cases at a higher risk of prolonged SRF.

摘要

目的

本研究旨在探讨初发（首次发作且未经治疗）中心性浆液性脉络膜视网膜病变（CSC）患者中视网膜下液（SRF）持续时间与基线脉络膜视网膜结构之间的关系。

方法

我们根据 SRF 液体从初始就诊时的持续时间，将 59 名患者分为非迁延组（<3 个月）和迁延组（>3 个月）。随访时间选择 SRF 消失时间和初始就诊后 3 个月之间的较短时间。我们使用频域光学相干断层扫描（SD-OCT）在初始就诊时测量中央视网膜厚度（CRT）、中央脉络膜厚度（CCT）、SRF 高度（SRFH）和外核层厚度（ONL），并记录 SRF 持续时间。我们比较了两组之间的这些参数，对 SRF 持续时间超过 3 个月进行了多变量分析，并研究了 CCT 与 CRT、SRFH 或 ONL 之间，以及 SRF 持续时间与 CRT、CCT、SRFH 或 ONL 之间的相关性。

结果

在初始就诊时，迁延组的 CCT 明显比非迁延组厚（P=0.044），且与 CRT 和 SRFH 显著相关（P=0.007，r=0.35 和 P=0.002，r=0.39）。SRF 持续时间与 CRT 和 SRFH 显著相关（P=0.009，r=0.40 和 P=0.003，r=0.41）。SRF 持续时间超过 3 个月的最佳模型包括年龄（P=0.054）和 CCT（P=0.008）。