叶酸缺乏所致脊髓亚急性联合变性：对甲基叶酸治疗的反应
Subacute combined degeneration of the cord due to folate deficiency: response to methyl folate treatment.
作者信息
Lever E G, Elwes R D, Williams A, Reynolds E H
出版信息
J Neurol Neurosurg Psychiatry. 1986 Oct;49(10):1203-7. doi: 10.1136/jnnp.49.10.1203.
Abstract
Subacute combined degeneration of the cord is a rare complication of folate deficiency. Disturbance of methylation reactions in nervous tissue probably underlie subacute combined degeneration of the cord arising from folate as well as vitamin B12 deficiency. Methyl tetrahydrofolate is the form in which folic acid is transported into the CNS. Therefore methyl tetrahydrofolate treatment of the neurological and psychiatric manifestations of folate deficiency would seem to be theoretically advantageous. A case of subacute combined degeneration of the cord due to dietary folate deficiency and associated with an organic brain syndrome is reported. There was striking haematological, neurological and psychiatric response to methyl folate treatment.
摘要
脊髓亚急性联合变性是叶酸缺乏的一种罕见并发症。神经组织中甲基化反应的紊乱可能是叶酸以及维生素B12缺乏所致脊髓亚急性联合变性的基础。甲基四氢叶酸是叶酸进入中枢神经系统的转运形式。因此，从理论上讲，用甲基四氢叶酸治疗叶酸缺乏的神经和精神表现似乎具有优势。本文报告一例因饮食中叶酸缺乏导致的脊髓亚急性联合变性病例，并伴有器质性脑综合征。甲基叶酸治疗后，血液学、神经学和精神方面均有显著改善。
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