Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren'ai Road, Suzhou, 215123, China.
Department of Laboratory, Suzhou Center for Disease Control and Prevention, 72 Sanxiang Road, Suzhou, Jiangsu, 215004, China.
Int J Hyg Environ Health. 2023 Sep;254:114270. doi: 10.1016/j.ijheh.2023.114270. Epub 2023 Oct 12.
To determine the relationships between circulating representative advanced glycation end products (AGEs) and cognitive performance in middle-aged and elderly Chinese adults.
A cross-sectional study with 1834 participants were included. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE). Plasma free AGEs including Nε-carboxymethyl-L-lysine (CML), Nε-(1-carboxyethyl) lysine (CEL), S-carboxymethyl-L-cysteine (CMC) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Multivariate adjusted linear and logistic regression analysis were used to explore the associations between plasma AGEs and cognitive function.
The prevalence of mild cognitive impairment (MCI) was 17.94%. Plasma CMC and MG-H1 level were negatively associated with MMSE score (β = -0.42, p < 0.001 for all) in the multivariate linear regression analysis. In the multivariate logistic regression analysis, compared to the lowest tertile, participants within the highest tertile of CMC and MG-H1 had increased risk of MCI [ORs (95% CI): 1.62 (1.21-2.17), P trend <0.001, and ORs (95% CI): 1.30 (0.97-1.76), P trend = 0.069, respectively]. In addition, the weighted quantile sum (WQS) index was negatively associated with MMSE (β = -0.48, P < 0.001) and increased risk of MCI [ORs (95% CI): 1.35 (1.20-1.52), P < 0.001].
Combined exposure of plasma free AGEs including CML, CEL, CMC and MG-H1 were associated with increased risk of cognitive impairment. Plasma CMC and MG-H1 might the main contributors for cognitive impairment, while further longitudinal studies are required to verify the associations.
探究循环中具有代表性的晚期糖基化终产物（AGEs）与中国中老年人群认知表现之间的关系。
该研究为横断面研究，共纳入 1834 名参与者。采用简易精神状态检查量表（MMSE）评估认知表现。采用超高效液相色谱-串联质谱法（UPLC-MS/MS）检测血浆游离 AGEs，包括 Nε-羧甲基赖氨酸（CML）、Nε-（1-羧乙基）赖氨酸（CEL）、S-羧甲基半胱氨酸（CMC）和 Nδ-（5-羟-5-甲基-4-咪唑啉-2-基）-鸟氨酸（MG-H1）。采用多元调整线性和逻辑回归分析来探讨血浆 AGEs 与认知功能之间的关系。
轻度认知障碍（MCI）的患病率为 17.94%。在多元线性回归分析中，血浆 CMC 和 MG-H1 水平与 MMSE 评分呈负相关（β=−0.42，p<0.001）。在多元逻辑回归分析中，与最低三分位组相比，CMC 和 MG-H1 最高三分位组的 MCI 风险增加[比值比（95%置信区间）：1.62（1.21-2.17），P 趋势<0.001，和比值比（95%置信区间）：1.30（0.97-1.76），P 趋势=0.069]。此外，加权中位数和（WQS）指数与 MMSE 呈负相关（β=−0.48，p<0.001），MCI 风险增加[比值比（95%置信区间）：1.35（1.20-1.52），p<0.001]。
包括 CML、CEL、CMC 和 MG-H1 的循环游离 AGEs 暴露与认知障碍风险增加相关。血浆 CMC 和 MG-H1 可能是认知障碍的主要原因，还需要进一步的纵向研究来验证这些关联。
