Noda H, Mikami A
J Neurophysiol. 1986 Oct;56(4):1129-46. doi: 10.1152/jn.1986.56.4.1129.
Extracellular recordings were obtained from 319 input units and 304 Purkinje cells (P-cells) in the dorsal paraflocculus of alert monkeys trained to fixate a visual target. They changed discharge rates with either eye movement, eye position, or visual stimulus movement. Of the 319 input units, recorded in the granular layer or white matter, most were mossy fibers (MFs), but 90 (28%) showed characteristic cellular spikes. The latter units were probably granular cells (p-GC). Of the 319 input units, 163 (51%) showed bursts with saccades (burst units) and 62 (19%) showed a prelude on the average 124 ms prior to the onset of saccade (long-lead burst units). Sixty-five (20%) had tonic activity related to eye position and also showed bursts with saccades (burst-tonic units), and the remaining 29 (9%) showed only tonic activity (tonic units). MFs and p-GCs showed no significant differences in the proportion of each type of unit or in their response properties. The majority of burst units (63%) were pan directional, whereas all long-lead burst units had directional selectivity. The preferred directions of long-lead burst, burst tonic, and directionally selective burst units were found in all four quadrants. Position-related activity was found in 48% of the burst-tonic and tonic units to be linearly related to eye position and to show position threshold. The other units also had position thresholds but their activity was not monotonically related to fixation position. Six climbing fibers (CFs), 32 input units (including 13 p-GC), and 8 P-cells showed cyclic responses during sinusoidal movements of a visual pattern. One class of MF units (57%) responded only to the direction, whereas the others responded to both the direction and retinal-slip velocity. Both CF and P-cell units responded to sinusoidal retinal-slip velocity. Of 67 input units, 23 showed cyclic modulation in firing during sinusoidal eye movements in the horizontal plane. Nineteen were burst-tonic and four were tonic units. They also showed position sensitivity. The phase of the cyclic responses tended to lag behind the eye velocity during low-frequency trackings. Of 237 P-cells, 163 (68.8%) discharged with saccades (burst P-cells), 42 (17.7%) paused with saccades (pause P-cells), and 32 (13.5%) discharged with saccades in one direction and paused in the other (burst-pause P-cells). Position sensitivity was found in 38 P-cells; 12 were burst, 5 were pause, and 10 were burst-pause P-cells. Eleven did not respond with saccades.(ABSTRACT TRUNCATED AT 400 WORDS)
在训练有素的警觉猴子的背侧副小叶中，从319个输入单元和304个浦肯野细胞（P细胞）获取了细胞外记录，这些猴子被训练注视视觉目标。它们的放电率会随着眼球运动、眼球位置或视觉刺激运动而改变。在颗粒层或白质中记录的319个输入单元中，大多数是苔藓纤维（MFs），但有90个（28%）表现出特征性的细胞锋电位。后一类单元可能是颗粒细胞（p-GC）。在319个输入单元中，163个（51%）在扫视时出现爆发（爆发单元），62个（19%）在扫视开始前平均124毫秒出现前奏（长潜伏期爆发单元）。65个（20%）具有与眼球位置相关的紧张性活动，并且在扫视时也出现爆发（爆发-紧张性单元），其余29个（9%）仅表现出紧张性活动（紧张性单元）。MFs和p-GCs在每种类型单元的比例或其反应特性方面没有显著差异。大多数爆发单元（63%）是全方向的，而所有长潜伏期爆发单元都具有方向选择性。长潜伏期爆发、爆发-紧张性和方向选择性爆发单元的偏好方向在所有四个象限中都有发现。在48%的爆发-紧张性和紧张性单元中发现了与位置相关的活动，与眼球位置呈线性相关并表现出位置阈值。其他单元也有位置阈值，但其活动与注视位置并非单调相关。在视觉模式的正弦运动期间，6根攀缘纤维（CFs）、32个输入单元（包括13个p-GC）和8个P细胞表现出周期性反应。一类MF单元（57%）仅对方向有反应，而其他单元对方向和视网膜滑动速度都有反应。CF和P细胞单元都对正弦视网膜滑动速度有反应。在67个输入单元中，23个在水平平面的正弦眼球运动期间放电出现周期性调制。19个是爆发-紧张性单元，4个是紧张性单元。它们也表现出位置敏感性。在低频跟踪期间，周期性反应的相位往往落后于眼球速度。在237个P细胞中，163个（68.8%）在扫视时放电（爆发P细胞），42个（17.7%）在扫视时暂停（暂停P细胞），32个（13.5%）在一个方向扫视时放电而在另一个方向扫视时暂停（爆发-暂停P细胞）。在38个P细胞中发现了位置敏感性；12个是爆发型，5个是暂停型，10个是爆发-暂停型P细胞。11个对扫视无反应。（摘要截于400字）
