Department of Plastic Surgery, MLB Medical College, Jhansi, India.
Department of Dentistry, Regional Training Centre for Oral Health Promotion, All India Institute of Medical Sciences, Bhopal, India.
Int Orthod. 2023 Dec;21(4):100816. doi: 10.1016/j.ortho.2023.100816. Epub 2023 Oct 11.
This systematic review and meta-analysis aimed to assess the effect of premature loss of primary teeth in children of mixed dentition age on the prevalence of malocclusion in permanent dentition.
A search was conducted in Medline through PubMed, Cochrane databases, Google Scholar, and Directory of Open Access Journals (DOAJ) through March 2023. All observational studies that evaluated the association between premature loss of primary teeth and malocclusion in permanent dentition were included for analysis. Quality of studies was evaluated using the Newcastle-Ottawa tool. Meta-analysis was conducted using Cochrane Review Manager (RevMan) Version 5.3. The association between different categories of malocclusion and premature loss of primary teeth was assessed using a random-effects model. Heterogeneity was explored through sensitivity analysis. Certainty of evidence was evaluated using GRADE analysis.
This meta-analysis showed that the premature loss of primary teeth significantly increases the prevalence of overall malocclusion in permanent dentition (OR=2.54, P=0.003; I: 83%). Subgroup analysis showed an insignificant relationship of premature loss of primary teeth with Class I malocclusion (OR=1.14, P=0.45; I: 63%) and Class II malocclusion (OR=1.63, P=0.18; I: 87%) but statistically significant relationship with Class III malocclusion (OR=3.73, P=0.006; I: 71%). Sensitivity analysis reflected a significant reduction in I values.
This meta-analysis provides substantial evidence supporting the relationship between premature loss of primary teeth and malocclusion in permanent dentition. Notably, Class III malocclusions exhibited a significant association with premature loss of primary teeth.
本系统评价和荟萃分析旨在评估儿童混合牙列期过早丧失乳牙对恒牙错牙合畸形患病率的影响。
通过 Medline 下的 PubMed、Cochrane 数据库、Google Scholar 和开放获取期刊目录（DOAJ）进行搜索，检索截至 2023 年 3 月。纳入所有评估乳牙过早丧失与恒牙错牙合畸形之间相关性的观察性研究进行分析。使用纽卡斯尔-渥太华量表评估研究质量。使用 Cochrane 评论经理（RevMan）版本 5.3 进行荟萃分析。使用随机效应模型评估不同错牙合畸形类别与乳牙过早丧失之间的关联。通过敏感性分析探索异质性。使用 GRADE 分析评估证据的确定性。
荟萃分析显示，乳牙过早丧失显著增加恒牙错牙合畸形总体患病率（OR=2.54，P=0.003；I²：83%）。亚组分析显示，乳牙过早丧失与 I 类错牙合畸形（OR=1.14，P=0.45；I²：63%）和 II 类错牙合畸形（OR=1.63，P=0.18；I²：87%）无显著相关性，但与 III 类错牙合畸形（OR=3.73，P=0.006；I²：71%）有统计学显著相关性。敏感性分析反映 I 值显著降低。
本荟萃分析提供了强有力的证据支持乳牙过早丧失与恒牙错牙合畸形之间的关系。值得注意的是，III 类错牙合畸形与乳牙过早丧失有显著关联。
