Li Zhi, Yin Peihao
Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China; Department of General surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188997. doi: 10.1016/j.bbcan.2023.188997. Epub 2023 Oct 12.
Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME plays an active role in promoting MDR through several pathways. However, a promising therapeutic approach for battling MDR involves targeting specific elements within the TME. Therefore, this comprehensive review elaborates on the research developments regarding the dual role of the TME in promoting and reversing MDR in cancer. Understanding the complex role of the TME in promoting and reversing MDR is essential to developing effective cancer therapies. Utilizing the adaptability of the TME by targeting novel TME-specific factors, utilizing combination therapies, and employing innovative treatment strategies can potentially combat MDR and achieve personalized treatment outcomes for patients with cancer.
多药耐药（MDR）对有效的癌症治疗构成了重大障碍，而肿瘤微环境（TME）对MDR的发展和逆转至关重要。TME通过多种途径在促进MDR方面发挥积极作用。然而，一种有前景的对抗MDR的治疗方法涉及靶向TME中的特定元素。因此，这篇全面综述阐述了关于TME在促进和逆转癌症MDR中的双重作用的研究进展。了解TME在促进和逆转MDR中的复杂作用对于开发有效的癌症治疗方法至关重要。通过靶向新型TME特异性因子利用TME的适应性、采用联合疗法以及运用创新治疗策略可能对抗MDR并为癌症患者实现个性化治疗结果。
