The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medicine, Guangzhou, Guangdong Province, P.R. China; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, P.R. China.
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, P.R. China.
Int Rev Neurobiol. 2023;172:285-301. doi: 10.1016/bs.irn.2023.07.003. Epub 2023 Sep 27.
Glioma cells are characterized by high migration ability, resulting in the aggressive growth of the tumors and poor prognosis of patients. Epithelial-to-mesenchymal transition (EMT) is one of the most important steps for tumor migration and metastasis and be elevated during glioma progression and recurrence. Twist1 is a basic helix-loop-helix transcription factor and a key transcription factor involved in the process of EMT. Twist1 is related to glioma mesenchymal change, invasion, heterogeneity, self-renewal of tumor stem cells, angiogenesis, etc., and may be used as a prognostic indicator and therapeutic target for glioma patients. This paper mainly reviews the structural characteristics, regulatory mechanisms, and apparent regulation of Twist1, as well as the roles of Twist1 during glioma progression and recurrence, providing new revelations for its use as a potential drug target and glioma treatment research.
神经胶质瘤细胞的迁移能力较强，这导致肿瘤的侵袭性生长和患者预后较差。上皮间质转化（EMT）是肿瘤迁移和转移的最重要步骤之一，在神经胶质瘤的进展和复发过程中会被上调。Twist1 是一个碱性螺旋环螺旋转录因子，是 EMT 过程中的关键转录因子。Twist1 与神经胶质瘤的间质变化、浸润、异质性、肿瘤干细胞的自我更新、血管生成等有关，可能作为神经胶质瘤患者的预后指标和治疗靶点。本文主要综述了 Twist1 的结构特征、调控机制及明显调控作用，以及在神经胶质瘤进展和复发过程中的作用，为将其作为潜在的药物靶点和神经胶质瘤治疗研究提供新的启示。
