Messer Nir, Melland Megan S, Miller Benjamin T, Krpata David M, Beffa Lucas R A, Zheng Xinyan, Petro Clayton C, Maskal Sara M, Ellis Ryan C, Prabhu Ajita S, Rosen Michael J
Cleveland Clinic Center for Abdominal Core Health, Department of General Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA; Department of Surgery, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel -Aviv University, Tel Aviv, Israel.
Cleveland Clinic Center for Abdominal Core Health, Department of General Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Am J Surg. 2024 Mar;229:52-56. doi: 10.1016/j.amjsurg.2023.09.013. Epub 2023 Sep 27.
Many studies identify active smoking as a significant risk factor for postoperative wound and mesh complications in patients undergoing abdominal wall reconstruction surgery. However, our group conducted an analysis using data from the ACHQC database, which revealed similar rates of surgical site infection (SSI) and surgical site occurrence requiring procedural intervention (SSOPI) between active smokers and non-smokers As a result, the Cl eveland Clinic Center for Abdominal Core Health instituted a policy change where active smokers were no longer subject to surgical delay. Our study aims to evaluate the impact of active smoking on the outcomes of these patients.
We identified active smoking patients who had undergone open, elective, clean ventral hernia repair (VHR) with transversus abdominis release (TAR) and permanent synthetic mesh at Cleveland Clinic Foundation. Propensity matching was performed to create a 1:3 ratio of "current-smokers" and "never-smokers" and compared wound complications and all 30-day morbidity between the two groups.
106 current-smokers and 304 never-smokers were matched. Demographics were similar between the two groups after matching, with the exception of chronic obstructive pulmonary disease (COPD) (22.1% vs. 13.4%, p < .001) and body mass index (BMI) (31.1 vs. 32.6, p = .02). Rates of SSI (12.2% vs. 6.9%, p = .13), SSO (21.7% vs. 13.2%, p = .052), SSOPI (11.3% vs. 6.3%, p = .13), and reoperation (1.9% vs. 3.9%, p = .53) were not significantly different between active smokers and never-smokers correspondingly. One case (0.3%) of partial mesh excision was observed in the never-smokers group (p = 1). The current-smokers group exhibited a significantly higher incidence of pneumonia compared to the never-smokers group (5.7% vs. 0.7%, p = .005).
Our study revealed that operating on active smokers did result in a slight increase in wound morbidity, although it did not reach statistical significance. Additionally, pulmonary complications were higher in the smoking group. Notably, we did not see any mesh infections in the smoking group during early follow up. We believe that this data is important for shared decision making on patients that are actively smoking contemplating elective hernia repair.
许多研究表明,主动吸烟是接受腹壁重建手术患者术后伤口和补片并发症的重要危险因素。然而,我们团队利用美国外科医师学会国家外科质量改进计划(ACHQC)数据库的数据进行分析,结果显示主动吸烟者和非吸烟者之间的手术部位感染(SSI)率以及需要进行手术干预的手术部位事件(SSOPI)发生率相近。因此,克利夫兰诊所腹壁核心健康中心更改了政策,不再因患者主动吸烟而延迟手术。我们的研究旨在评估主动吸烟对这些患者手术结果的影响。
我们在克利夫兰诊所基金会确定了接受开放性择期清洁性腹横肌松解(TAR)及永久性合成补片修补腹直肌前鞘缺损(VHR)的主动吸烟患者。进行倾向得分匹配,以建立“当前吸烟者”与“从不吸烟者”1:3的比例,并比较两组之间的伤口并发症及所有30天内的发病率。
匹配了106名当前吸烟者和304名从不吸烟者。匹配后两组的人口统计学特征相似,但慢性阻塞性肺疾病(COPD)(22.1%对13.4%,p<0.001)和体重指数(BMI)(31.1对32.6,p = 0.02)除外。主动吸烟者与从不吸烟者的SSI发生率(12.2%对6.9%,p = 0.13)、手术部位事件(SSO)发生率(21.7%对13.2%,p = 0.052)、SSOPI发生率(11.3%对6.3%,p = 0.13)及再次手术率(1.9%对3.9%,p = 0.53)相应地均无显著差异。从不吸烟者组观察到1例(0.3%)部分补片切除病例(p = 1)。与从不吸烟者组相比,当前吸烟者组肺炎发生率显著更高(5.7%对0.7%,p = 0.005)。
我们的研究表明,对主动吸烟者进行手术确实会导致伤口发病率略有上升,尽管未达到统计学显著性。此外,吸烟组的肺部并发症更高。值得注意的是,在早期随访期间,我们在吸烟组中未发现任何补片感染情况。我们认为,这些数据对于正在考虑择期疝修补术的主动吸烟患者的共同决策具有重要意义。