Department of Hematology, Hokkaido University Hospital, N15 W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan.
Sci Rep. 2023 Oct 13;13(1):17374. doi: 10.1038/s41598-023-43806-3.
Hepatic sinusoidal obstruction syndrome (SOS) is a severe and life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a multi-center retrospective study to evaluate the utility of our ultrasonographic scoring system for the diagnosis of SOS (HokUS-10) in predicting SOS-related mortality (SOS-RM). We analyzed a total of 42 patients who developed SOS after HSCT. The cumulative incidences of SOS-RM, non-relapse mortality (NRM), and overall survival at day 180 after the diagnosis of SOS were 26.4%, 28.8% and 54.5%, respectively. The area under the receiver operating characteristic curve analysis showed that the optimal cut-off value of HokUS-10 total score to predict SOS-RM was 8 points after the treatment of SOS. In the individual HokUS-10 score, ascites and portal vein flow-related scores (PV mean velocity and PV flow direction) after the treatment of SOS were shown as significant risk factors for SOS-RM. Our study suggested that US findings after the treatment can predict the treatment outcomes for SOS.
肝窦阻塞综合征（SOS）是异基因造血干细胞移植（HSCT）后一种严重且危及生命的并发症。我们进行了一项多中心回顾性研究，以评估我们的超声评分系统（HokUS-10）对 SOS 的诊断在预测 SOS 相关死亡率（SOS-RM）中的效用。我们分析了总共 42 名在 HSCT 后发生 SOS 的患者。SOS 诊断后 180 天 SOS-RM、非复发死亡率（NRM）和总生存率的累积发生率分别为 26.4%、28.8%和 54.5%。受试者工作特征曲线分析显示，治疗 SOS 后 HokUS-10 总分预测 SOS-RM 的最佳截断值为 8 分。在单个 HokUS-10 评分中，SOS 治疗后的腹水和门静脉血流相关评分（PV 平均速度和 PV 血流方向）是 SOS-RM 的显著危险因素。我们的研究表明，治疗后超声表现可以预测 SOS 的治疗结果。
