Saugstad O D, Ziegler M G, Kessel B, Saunders B, Gluck L
J Perinat Med. 1986;14(5):339-43.
Hypoxanthine and the catecholamines, dopamine, norepinephrine and epinephrine were determined in umbilical venous cord plasma in 27 term babies delivered vaginally. When correlating hypoxanthine with log epinephrine a weak positive linear correlation was found (r = 0.45, p less than 0.05). The correlation between hypoxanthine and log dopamine showed a significant negative linear correlation (r = -0.65, p less than 0.01). There was also a significant correlation between log epinephrine and pH (r = 0.72, P less than 0.01) and base deficit (r = 0.46, P less than 0.05). In four babies who suffered intrauterine hypoxia, hypoxanthine was significantly elevated compared with non hypoxic babies (21.4 +/- 5.1 versus 6.3 +/- 6.6 mumol/l, P less than 0.01). In these babies norepinephrine (3710 +/- 3888 vs 789 +/- 718 Pg/ml, P less than 0.01) and epinephrine (298 +/- 229 vs 148 +/- 116 Pg/ml, P less than 0.05) were significantly elevated as well, in contrast to dopamine levels (188 +/- 94 vs 169 +/- 134 Pg/ml N. S.). This finding seems to indicate that dopamine synthesis goes down during hypoxia probably because the rate limiting enzyme in dopamine synthesis, tyrosine, hydroxylase, is inhibited in hypoxia.
对27名经阴道分娩的足月儿的脐静脉血浆中的次黄嘌呤、儿茶酚胺、多巴胺、去甲肾上腺素和肾上腺素进行了测定。将次黄嘌呤与肾上腺素对数进行相关性分析时，发现呈弱正线性相关（r = 0.45，p < 0.05）。次黄嘌呤与多巴胺对数之间的相关性呈显著负线性相关（r = -0.65，p < 0.01）。肾上腺素对数与pH值（r = 0.72，P < 0.01）和碱缺失（r = 0.46，P < 0.05）之间也存在显著相关性。在4名遭受宫内缺氧的婴儿中，与非缺氧婴儿相比，次黄嘌呤显著升高（21.4±5.1对6.3±6.6μmol/l，P < 0.01）。在这些婴儿中，去甲肾上腺素（3710±3888对789±718Pg/ml，P < 0.01）和肾上腺素（298±229对148±116Pg/ml，P < 0.05）也显著升高，而多巴胺水平（188±94对169±134Pg/ml，无显著性差异）则相反。这一发现似乎表明，在缺氧期间多巴胺合成下降，可能是因为多巴胺合成中的限速酶酪氨酸羟化酶在缺氧时受到抑制。
