Kutzman R S, Wehner R W, Haber S B
J Environ Pathol Toxicol Oncol. 1986 May-Aug;6(5-6):97-108.
The Dahl selected rat lines, one susceptible to salt-induced hypertension (DS) and the other resistant to salt-induced hypertension (DR), were subchronically exposed to filtered air, 0.4, 1.4, or 4.0 ppm acrolein. All of the DS rats exposed to 4.0 ppm acrolein died within the first 11 days, while 60% of the DR animals survived. Neither dose dependent blood pressure changes nor altered behavioral characteristics were evident following acrolein exposure. Exposure to 4.0 ppm acrolein increased the level of several serum enzymes. This concentration of acrolein also led to pulmonary edema and a significant increase in lung connective tissue. There was a marked difference in the pulmonary pathology observed in DS and DR rats exposed to 4.0 ppm acrolein. The lungs of the DS rats exhibited severe airway epithelial necrosis with edema and hemorrhage, while surviving DR rats primarily showed a proliferative change. Following exposure to 0.4 to 1.4 ppm acrolein, both rat lines displayed similar pathologic change. Epithelial hyperplasia and/or clusters of macrophages were usually found near terminal bronchiolar areas. These findings suggest that further investigation of the physiopathologic sensitivity of the DS rat line may elucidate a model for investigating the underlying characteristics of stress susceptible populations.
选择了达尔大鼠品系，一种对盐诱导性高血压敏感（DS），另一种对盐诱导性高血压有抗性（DR），将它们亚慢性暴露于过滤空气、0.4、1.4或4.0 ppm的丙烯醛中。所有暴露于4.0 ppm丙烯醛的DS大鼠在最初11天内死亡，而60%的DR动物存活下来。丙烯醛暴露后，既没有明显的剂量依赖性血压变化，行为特征也没有改变。暴露于4.0 ppm丙烯醛会使几种血清酶水平升高。这种浓度的丙烯醛还会导致肺水肿和肺结缔组织显著增加。在暴露于4.0 ppm丙烯醛的DS和DR大鼠中观察到的肺部病理学有明显差异。DS大鼠的肺部表现出严重的气道上皮坏死并伴有水肿和出血，而存活的DR大鼠主要表现为增殖性变化。暴露于0.4至1.4 ppm丙烯醛后，两个大鼠品系都表现出相似的病理变化。上皮增生和/或巨噬细胞簇通常出现在终末细支气管区域附近。这些发现表明，进一步研究DS大鼠品系的生理病理敏感性可能会阐明一种用于研究应激易感人群潜在特征的模型。
