Zhang Mengsi, Wang Xinyuan, Zhang Shuo, Wang Tiebao, Wang Xin, Liu Shuiqing, Zhao Lichen, Cui Chunxiang
Key Laboratory for New Type of Functional Materials in Hebei Province, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China.
School of Mechanical Engineering, Hebei University of Technology, Tianjin 300130, China.
Materials (Basel). 2023 Sep 27;16(19):6432. doi: 10.3390/ma16196432.
In recent years, Zn and its alloys have become some of the most promising degradable metals as in vivo implants due to their acceptable biocompatibility and more suitable degradation rate compared with Mg-based and Fe-based alloys. However, the degradation rate of Zn-based materials after implantation in the body for orthopedic applications is relatively slow, leading to long-term retention of the implants after fulfilling their missions. Moreover, the excessive release of Zn during the degradation process of Zn-based implants usually leads to high cytotoxicity and delayed osseointegration. To provide a feasible solution to the problem faced by Zn-based implants, a Zn-Ca composite was fabricated by an air pressure infiltration method in this work. The XRD pattern of the composite suggests that the composite is fully composed of Zn-Ca intermetallic compounds. The degradation tests in vitro show that the composite has a much higher degradation rate than pure Zn, and the high Ca content regions in the composite can preferentially degrade as sacrificial anodes. In addition, the composite can efficiently induce Ca-P deposition during immersion tests in Hank's solution. Cytotoxicity tests indicate that L-929 cells exhibit around 82% cell viability (Grade 1) even after being cultured in the 100% extract prepared from the Zn-Ca composite for 1 day and show excellent cell viability.
近年来，锌及其合金因其可接受的生物相容性以及与镁基和铁基合金相比更合适的降解速率，已成为体内植入物中最有前景的可降解金属之一。然而，用于骨科应用的锌基材料植入体内后的降解速率相对较慢，导致植入物在完成其使命后长期留存。此外，锌基植入物降解过程中锌的过度释放通常会导致高细胞毒性和延迟骨整合。为了为锌基植入物面临的问题提供一个可行的解决方案，本研究通过气压浸渗法制备了一种锌钙复合材料。该复合材料的XRD图谱表明，该复合材料完全由锌钙金属间化合物组成。体外降解试验表明，该复合材料的降解速率比纯锌高得多，复合材料中的高钙含量区域可以作为牺牲阳极优先降解。此外，在汉克溶液中浸泡试验期间，该复合材料可以有效地诱导钙磷沉积。细胞毒性试验表明，L-929细胞即使在由锌钙复合材料制备的100%提取物中培养1天后，仍表现出约82%的细胞活力（1级），并显示出优异的细胞活力。
