非编码RNA在骨髓增生异常综合征中的作用
The Role of Non-Coding RNAs in Myelodysplastic Neoplasms.
作者信息
Georgoulis Vasileios, Koumpis Epameinondas, Hatzimichael Eleftheria
机构信息
Department of Haematology, University Hospital of Ioannina, Faculty of Medicine, University of Ioannina, 45 500 Ioannina, Greece.
Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19 107, USA.
出版信息
Cancers (Basel). 2023 Sep 30;15(19):4810. doi: 10.3390/cancers15194810.
Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.
骨髓增生异常综合征或肿瘤（MDS）是一组异质性的髓系克隆性疾病，其特征为外周血细胞减少、血液和骨髓细胞发育异常，以及进展为急性髓系白血病（AML）的风险增加。非编码RNA，尤其是微小RNA和长链非编码RNA，作为正常和恶性造血的调节因子，并与肿瘤发生有关。本综述全面总结了非编码RNA的生物学特性和作用，包括研究较少的环状RNA、小干扰RNA、Piwi相互作用RNA和核仁小分子RNA，它们作为MDS潜在的预后和/或预测生物标志物或治疗靶点。
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