Sang Yizhen, Tsuji Kenji, Nakanoh Hiroyuki, Fukushima Kazuhiko, Kitamura Shinji, Wada Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Department of Rheumatology and Immunology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Diagnostics (Basel). 2023 Sep 25;13(19):3038. doi: 10.3390/diagnostics13193038.
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving in the several pathogeneses of diseases, including eyes and neurons, as well as kidneys. SEMA3A is expressed in podocytes and tubular cells in the normal adult kidney, and recent evidence has revealed that excess SEMA3A expression and the subsequent signaling pathway aggravate kidney injury in a variety of kidney diseases, including nephrotic syndrome, diabetic nephropathy, acute kidney injury, and chronic kidney disease. In addition, several reports have demonstrated that the inhibition of SEMA3A ameliorated kidney injury via a reduction in cell apoptosis, fibrosis and inflammation; thus, SEMA3A may be a potential therapeutic target for kidney diseases. In this review article, we summarized the current knowledge regarding the role of SEMA3A in kidney pathophysiology and their potential use in kidney diseases.
肾脏疾病是影响数百万人的全球性公共卫生问题。然而，针对肾脏疾病的治疗选择仍然有限。信号素3A（SEMA3A）是一种分泌型和膜相关蛋白，它调节多种功能，包括免疫调节、细胞存活、迁移和血管生成，因此涉及包括眼睛、神经元以及肾脏在内的多种疾病的发病机制。SEMA3A在正常成年肾脏的足细胞和肾小管细胞中表达，最近的证据表明，SEMA3A表达过量及随后的信号通路会加重包括肾病综合征、糖尿病肾病、急性肾损伤和慢性肾脏病在内的多种肾脏疾病中的肾损伤。此外，一些报告表明，抑制SEMA3A可通过减少细胞凋亡、纤维化和炎症来改善肾损伤；因此，SEMA3A可能是肾脏疾病的一个潜在治疗靶点。在这篇综述文章中，我们总结了目前关于SEMA3A在肾脏病理生理学中的作用及其在肾脏疾病中的潜在用途的知识。
