Department of Nephrology, Xi'an Children's Hospital, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an 710003, China.
Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Nutrients. 2023 Sep 30;15(19):4227. doi: 10.3390/nu15194227.
The connection between the gut microbiota and brain structure changes is still unclear. We conducted a Mendelian randomization (MR) study to examine the bidirectional causality between the gut microbiota (211 taxa, including 131 genera, 35 families, 20 orders, 16 classes and 9 phyla; N = 18,340 individuals) and age-independent/dependent longitudinal changes in brain structure across the lifespan (N = 15,640 individuals aged 4~99 years). We identified causal associations between the gut microbiota and age-independent/dependent longitudinal changes in brain structure, such as family with age-independent longitudinal changes of cortical gray matter (GM) volume and genus with age-independent average cortical thickness and cortical GM volume. Taking age-independent longitudinal changes in brain structure across the lifespan as exposures, there were causal relationships between the surface area and genus . Our findings may serve as fundamentals for further research on the genetic mechanisms and biological treatment of complex traits and diseases associated with the gut microbiota and the brain structure change rate.
肠道微生物群与大脑结构变化之间的联系尚不清楚。我们进行了一项孟德尔随机化（MR）研究，以检查肠道微生物群（211 个分类群，包括 131 个属、35 个科、20 个目、16 个纲、9 个门；N=18340 人）与终生大脑结构的年龄独立/依赖纵向变化（N=15640 名年龄在 4 至 99 岁的个体）之间的双向因果关系。我们确定了肠道微生物群与大脑结构的年龄独立/依赖纵向变化之间的因果关系，例如，家族与皮质灰质（GM）体积的年龄独立纵向变化有关，而属与平均皮质厚度和皮质 GM 体积的年龄独立有关。以终生大脑结构的年龄独立纵向变化为暴露因素，大脑表面积与属之间存在因果关系。我们的研究结果可能为进一步研究与肠道微生物群和大脑结构变化率相关的复杂特征和疾病的遗传机制和生物治疗提供基础。
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