Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil.
SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, Brazil.
Molecules. 2023 Sep 26;28(19):6807. doi: 10.3390/molecules28196807.
It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease transmission is related to the poor sanitation and hygiene habits that affect residents of impoverished regions in tropical and subtropical countries. The main species responsible for causing disease in humans are , , and , each with different geographic distributions. Praziquantel is the drug predominantly used to treat this disease, which offers low effectiveness against immature and juvenile parasite forms. In addition, reports of drug resistance prompt the development of novel therapeutic approaches. Natural products represent an important source of new compounds, especially those obtained from plant sources. This review compiles data from several in vitro and in vivo studies evaluating various compounds and essential oils derived from plants with cercaricidal and molluscicidal activities against both juvenile and adult forms of the parasite. Finally, this review provides an important discussion on recent advances in molecular and computational tools deemed fundamental for more rapid and effective screening of new compounds, allowing for the optimization of time and resources.
据估计，全球有 2.5 亿人受到血吸虫病的影响。疾病传播与影响热带和亚热带国家贫困地区居民的卫生和卫生习惯差有关。主要引起人类疾病的物种是 、 和 ，每个物种的地理分布都不同。吡喹酮是治疗这种疾病的主要药物，但对未成熟和幼年寄生虫形式的疗效较低。此外，耐药性的报告促使人们开发新的治疗方法。天然产物是新化合物的重要来源，特别是那些从植物来源获得的化合物。本综述汇总了多项体外和体内研究的数据，评估了对寄生虫幼体和成虫形式均具有杀尾蚴和杀螺活性的各种化合物和植物精油。最后，本综述对分子和计算工具的最新进展进行了重要讨论，这些工具被认为是对新化合物进行更快速和有效的筛选的基础，从而可以优化时间和资源。
