Department of Animal Production, College of Agriculture, Al-Qasim Green University, Al-Qasim 8, Babil, 51001, Iraq.
College of Medicine, University of Warith Al-Anbiyaa, Karbala, 56001, Iraq.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr;397(4):2021-2053. doi: 10.1007/s00210-023-02756-3. Epub 2023 Oct 14.
The Oldenlandia genus comprises approximately 240 species of plants, yet only a limited number of these have been investigated for their chemical composition and medicinal properties. These species contain a wide range of compounds such as iridoids, anthraquinones, triterpenes, phytosterols, flavonoids, anthocyanidins, vitamins, essential oils, phenolic acids, and coumarins. These diverse phytochemical profiles underscore the pharmacological potential of Oldenlandia plants for various medical purposes. Among other chemical constituents, ursolic acid stands out as the most important active compound in Oldenlandia, owing to its proven anticancer, anti-inflammatory, antimicrobial, and hepatoprotective properties. The evaluation of Oldenlandia's pharmacological prospects indicates that the holistic utilization of the entire plant yields the most significant effects. Oldenlandia diffusa showcases anticancer and anti-inflammatory capabilities attributed to its varying constituents. Across a broad spectrum of pharmacological capacities, anticancer research predominates, constituting the majority of medical uses. Oldenlandia diffusa emerges as a standout for its remarkable anticancer effects against diverse malignancies. Antioxidant applications follow, with O. corymbosa demonstrating potent antioxidant properties alongside O. umbellata and O. diffusa. Subsequent priority lies in anti-inflammatory studies, wherein O. diffusa exhibits noteworthy efficacy, trailed by O. corymbosa also takes the lead in antimicrobial activity, with O. umbellata as a strong contender. Additional investigation is essential to ascertain the relative significance of these species in various pharmacological applications. This comprehensive assessment underscores the multifaceted potential of Oldenlandia as a versatile herbal resource, offering diverse pharmacological capacities. The call for sustained exploration and research remains essential to unlock the full extent of Oldenlandia's medicinal benefits.
鸡矢藤属约有 240 种植物，但仅有少数几种因其化学成分和药用特性而被研究。这些物种含有广泛的化合物，如环烯醚萜、蒽醌、三萜、植物甾醇、类黄酮、花青素、维生素、精油、酚酸和香豆素。这些多样化的植物化学特征突显了鸡矢藤植物在各种医疗用途中的药理学潜力。在其他化学成分中，熊果酸是鸡矢藤中最重要的活性化合物，因为它具有已被证明的抗癌、抗炎、抗菌和保肝作用。对鸡矢藤药理学前景的评估表明，整体利用整个植物会产生最显著的效果。鸡矢藤 diffusa 因其不同的成分而具有抗癌和抗炎能力。在广泛的药理学能力中，抗癌研究占主导地位，构成了大多数医疗用途。鸡矢藤 diffusa 因其对多种恶性肿瘤的显著抗癌作用而脱颖而出。抗氧化剂应用紧随其后，O. corymbosa 表现出强大的抗氧化特性，而 O. umbellata 和 O. diffusa 也具有抗氧化特性。其次是抗炎研究，鸡矢藤 diffusa 表现出显著的疗效，其次是 O. corymbosa 在抗菌活性方面也处于领先地位，而 O. umbellata 则是强有力的竞争者。需要进一步的研究来确定这些物种在各种药理学应用中的相对重要性。这种全面的评估突显了鸡矢藤作为一种多用途草药资源的多方面潜力，提供了多样化的药理学能力。持续探索和研究仍然是必要的，以充分发挥鸡矢藤的药用价值。
