Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Gastroenterology, Shangyu People's Hospital, Shaoxing, Zhejiang, China.
Nutrition. 2024 Jan;117:112214. doi: 10.1016/j.nut.2023.112214. Epub 2023 Sep 9.
The aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio, an indicator for liver fibrosis, could be easily detected in clinical practice. The aim of this study was to examine the association between the AST/ALT ratio and skeletal muscle mass among Chinese community adult residents.
We enrolled 2644 participants, age ≥18 y, undergoing bioelectrical impedance analysis and liver function test. Univariate and multivariate logistic regression models were used to analyze the effect of the AST/ALT ratio on the presence of low muscle mass (LMM). Multiple linear regression analysis was used to assess the factors associated with the skeletal muscle mass index (SMI) and to construct a formula to calculate the SMI.
When the AST/ALT ratio was regarded as a categorical variable, AST/ALT quartiles 9-2.19) kept independent effects on the presence of LMM status. When it was regarded as a continuous variable, each unit of the AST/ALT ratio was significantly associated with a 49% (P < 0.01) augment of the prevalence of LMM. By multiple general linear regression analysis, the formula was constructed with an adjusted R of 0.72: SMI (kg/m) = -0.14 AST/ALT ratio + 1.35 sex (male: 1; female: 0) + 0.72 overweight status (yes: 1; no: 0) - 0.14 age (≤65: 0; >65: 1) + 6.26.
In general, the high AST/ALT ratio was an independent adverse indicator of the presence of LMM.
天冬氨酸氨基转移酶/丙氨酸氨基转移酶（AST/ALT）比值是肝纤维化的一个指标，在临床实践中易于检测。本研究旨在探讨该比值与中国社区成年居民骨骼肌量之间的关系。
我们纳入了 2644 名年龄≥18 岁的接受生物电阻抗分析和肝功能检测的参与者。采用单因素和多因素 logistic 回归模型分析 AST/ALT 比值对低肌肉量（LMM）的影响。采用多元线性回归分析评估与骨骼肌量指数（SMI）相关的因素，并构建一个计算公式来计算 SMI。
当 AST/ALT 比值被视为分类变量时，AST/ALT 四分位数 3（2.19-3.54）和 4（3.54-9）与 LMM 状态的存在具有独立影响。当 AST/ALT 比值被视为连续变量时，每单位 AST/ALT 比值与 LMM 患病率增加 49%（P < 0.01）显著相关。通过多元广义线性回归分析，构建了一个调整后的 R²为 0.72 的公式：SMI（kg/m）=-0.14 AST/ALT 比值+1.35 性别（男：1；女：0）+0.72 超重状态（是：1；否：0）-0.14 年龄（≤65：0；>65：1）+6.26。
一般而言，高 AST/ALT 比值是 LMM 存在的独立不利指标。
