Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Department of Dental Anesthesiology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
J Neurol Sci. 2023 Nov 15;454:120831. doi: 10.1016/j.jns.2023.120831. Epub 2023 Oct 10.
Several noninvasive tools assess swallowing disorders, including electronic stethoscope artificial intelligence (AI) analysis for remote diagnosis, with the potential for telemedicine. This study investigated the swallowing sound index in patients with Parkinson's disease (PD).
This single-arm, open-label trial assessed the impact of cervical percutaneous interferential current stimulation on swallowing in patients with PD classified as Hoehn-Yahr stages 2-4. Stimulation was conducted for 8 weeks. Baseline data were used to examine the link between the swallowing sound index and indicators such as videofluoroscopy (VF). Furthermore, we examined changes in the swallowing sound index after the intervention.
Twenty-five patients were included. The swallowing sound index in patients with PD was higher than that in those with amyotrophic lateral sclerosis but considerably lower than that in healthy controls. The number of patients with normal EAT-10 scores positively correlated with the swallowing sound index, whereas elevated C-reactive protein levels were negatively correlated with the swallowing sound index. However, the index displayed no correlation with other indicators, including the VF results. Despite the intervention, the index remained unchanged throughout the study.
In patients with PD, a decrease in the swallowing sound index suggests a potential association between swallowing disorders and the risk of aspiration pneumonia.
jRCTs062220013.
有几种非侵入性工具可评估吞咽障碍，包括电子听诊器人工智能（AI）分析用于远程诊断，具有远程医疗的潜力。本研究调查了帕金森病（PD）患者的吞咽声指数。
这项单臂、开放标签试验评估了颈内经皮干扰电流刺激对 Hoehn-Yahr 分期 2-4 期 PD 患者吞咽的影响。刺激持续 8 周。使用基线数据来检查吞咽声指数与视频透视（VF）等指标之间的关系。此外，我们还检查了干预后吞咽声指数的变化。
共纳入 25 例患者。PD 患者的吞咽声指数高于肌萎缩侧索硬化症患者，但明显低于健康对照组。EAT-10 评分正常的患者数量与吞咽声指数呈正相关，而 C 反应蛋白水平升高与吞咽声指数呈负相关。然而，该指数与包括 VF 结果在内的其他指标均无相关性。尽管进行了干预，但整个研究过程中该指数均保持不变。
在 PD 患者中，吞咽声指数降低提示吞咽障碍与吸入性肺炎风险之间存在潜在关联。
jRCTs062220013。
