School of Life Science, Beijing Institute of Technology, Beijing, China.
School of Medical Technology, Beijing Institute of Technology, Beijing, China.
Neurobiol Dis. 2023 Nov;188:106323. doi: 10.1016/j.nbd.2023.106323. Epub 2023 Oct 12.
Parkinson's disease (PD) has been showed perfusion and neural activity alterations in specific regions, such as the motor and visual networks; however, the clinical significance of coupling changes is still unknown. To identify how neurovascular coupling changes during the pathophysiology of PD, patients and healthy controls underwent multiparametric magnetic resonance imaging to measure neural activity organization of segregation and integration using amplitude of low-frequency fluctuation (ALFF) and functional connectivity strength (FCS), and measure vascular responses using cerebral blood flow (CBF). Neurovascular coupling was calculated as the global CBF-ALFF and CBF-FCS coupling and the regional CBF/ALFF and CBF/FCS ratio. Correlations and dynamic causal modeling was then used to evaluate relationships with disease-alterations to clinical variables and information flow. Neurovascular coupling was impaired in PD with decreased global CBF-ALFF and CBF-FCS coupling, as well as decreased CBF/ALFF in the parieto-occipital cortex (dorsal visual stream) and CBF/FCS in the temporo-occipital cortex (ventral visual stream); these decouplings were associated with motor and non-motor impairments. The distinctive patterns of neurovascular coupling alterations within the dorsal and ventral visual streams of the visual system could potentially provide additional understanding into the pathophysiological mechanisms of PD.
帕金森病 (PD) 已显示在特定区域（如运动和视觉网络）存在灌注和神经活动改变；然而，耦合变化的临床意义仍不清楚。为了确定 PD 病理生理学过程中神经血管耦合如何变化，患者和健康对照者接受了多参数磁共振成像，以使用低频波动幅度 (ALFF) 和功能连接强度 (FCS) 测量分离和整合的神经活动组织，并使用脑血流 (CBF) 测量血管反应。神经血管耦合通过全局 CBF-ALFF 和 CBF-FCS 耦合以及局部 CBF/ALFF 和 CBF/FCS 比来计算。然后使用相关性和动态因果建模来评估与疾病改变与临床变量和信息流的关系。PD 患者的神经血管耦合受损，表现为全局 CBF-ALFF 和 CBF-FCS 耦合降低，以及顶枕叶皮层（背侧视觉流）的 CBF/ALFF 和颞枕叶皮层（腹侧视觉流）的 CBF/FCS 降低；这些解耦与运动和非运动障碍有关。视觉系统中背侧和腹侧视觉流内神经血管耦合改变的独特模式可能为 PD 的病理生理机制提供更多的理解。
