Department of Family Medicine (F-HS), Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, Taiwan; School of Medicine (F-HS), College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
School of Public Health (M-JS, M-ZY, MM, C-CY), College of Public Health, Taipei Medical University, New Taipei City, Taiwan; Department of Laboratory Medicine (M-JS), Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Am J Geriatr Psychiatry. 2024 Feb;32(2):180-191. doi: 10.1016/j.jagp.2023.09.011. Epub 2023 Sep 17.
To evaluate the risk of cognitive impairment among patients with chronic viral hepatitis.
A cross-sectional study.
Population-based.
Individuals 60 years or older were enrolled from the Taiwan Biobank database from 2012.
Hepatitis B virus and hepatitis C virus infections.
Cognitive impairment was evaluated using the mini-mental state examination (MMSE). Logistic regression models were used to calculate odds ratios and 95% confidence intervals (CIs). The effects of APOE ε4 polymorphisms on the association between viral hepatitis and the risk of cognitive impairment were also investigated.
We recruited 912 participants with cognitive impairment and 22 869 participants without cognitive impairment. The adjusted odds ratio (aOR) for cognitive impairment was 1.38 (95% CI: 1.03-1.85, p = 0.033) among participants with hepatitis C virus infection and 1.14 (95% CI: 0.91-1.43, p = 0.257) among participants with hepatitis B virus infection. Participants with hepatitis C virus infection and without hepatitis B virus infection had a higher risk of cognitive impairment (aOR: 1.52, 95% CI: 1.13-2.04, p = 0.006). The MMSE subcategories most associated with hepatitis C virus infection were orientation and design copying. The association between hepatitis C virus infection and cognitive impairment was higher among participants with ε4 alleles of the APOE gene than among those without alleles (aOR: 2.18, 95% CI: 1.21-3.91, p = 0.009).
Our findings suggest that individuals 60 years or older with chronic hepatitis C virus infection are at increased risk of cognitive impairment.
评估慢性病毒性肝炎患者认知障碍的风险。
横断面研究。
基于人群。
2012 年从台湾生物库数据库中招募了 60 岁或以上的个体。
乙型肝炎病毒和丙型肝炎病毒感染。
使用简易精神状态检查（MMSE）评估认知障碍。使用逻辑回归模型计算比值比和 95%置信区间（CI）。还研究了 APOE ε4 多态性对病毒肝炎与认知障碍风险之间关联的影响。
我们招募了 912 名认知障碍患者和 22869 名无认知障碍患者。调整后的比值比（aOR）为丙型肝炎病毒感染者为 1.38（95%CI：1.03-1.85，p=0.033），乙型肝炎病毒感染者为 1.14（95%CI：0.91-1.43，p=0.257）。丙型肝炎病毒感染且无乙型肝炎病毒感染者认知障碍风险较高（aOR：1.52，95%CI：1.13-2.04，p=0.006）。与丙型肝炎病毒感染最相关的 MMSE 亚类是定向和设计复制。APOE 基因 ε4 等位基因携带者丙型肝炎病毒感染与认知障碍的关联高于无等位基因携带者（aOR：2.18，95%CI：1.21-3.91，p=0.009）。
我们的研究结果表明，60 岁或以上患有慢性丙型肝炎病毒感染的个体发生认知障碍的风险增加。
