Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
World J Urol. 2023 Dec;41(12):3753-3758. doi: 10.1007/s00345-023-04657-9. Epub 2023 Oct 14.
To investigate the association between low-dose aspirin use for primary prevention and self-reported kidney stones prevalence in the 40-79 years old population.
We conducted a cross-sectional study based on the United States population data from the National Health and Nutrition Examination Survey 2011-2018. Baseline demographical and clinical data were collected. The univariate and multivariate regression was performed to identify confounding factors and assess the relationship between aspirin use for primary prevention and the prevalence of self-reported kidney stones. A propensity-score matching was used to identify patients with similar baseline characteristics to adjust for the bias caused by confounding factors.
A total of 10,256 low-dose aspirin-use participants were included in this study. 10.4% of participants reported a history of kidney stones, and 18.5% reported a continuous use of low-dose prophylactic aspirin. Multivariate logistic regression analysis showed that low-dose preventive aspirin use had significantly increased the odds of self-reported kidney stones (OR = 1.245; 95% CI: 1.063-1.459; p = 0.007). In subgroup analysis, this finding was primarily limited to males (OR = 1.311), non-hypertensive participants (OR = 1.443), diabetic participants (OR = 1.380), and older (60 ≤ Age < 80) (OR = 1.349). The propensity-score matched analyses supported this result after adjusting for the bias caused by potential confounders (OR = 1.216; 95% CI: 1.011-1.462; p = 0.038).
In this study, there exists a significant relationship between low-dose aspirin for primary prevention and self-reported kidney stones, primarily among males, no hypertensive participants, diabetics, or older adults. Further studies are needed to elucidate the mechanisms underlying these findings in the future.
研究低剂量阿司匹林用于一级预防与 40-79 岁人群自我报告肾结石患病率之间的关系。
我们基于美国国家健康和营养检查调查 2011-2018 年的数据进行了一项横断面研究。收集了基线人口统计学和临床数据。采用单变量和多变量回归分析确定混杂因素，并评估阿司匹林用于一级预防与自我报告肾结石患病率之间的关系。采用倾向评分匹配来识别具有相似基线特征的患者，以调整混杂因素引起的偏倚。
本研究共纳入 10256 名低剂量阿司匹林使用者。10.4%的参与者报告有肾结石病史，18.5%的参与者报告持续使用低剂量预防性阿司匹林。多变量逻辑回归分析显示，低剂量预防性阿司匹林的使用显著增加了自我报告肾结石的几率（OR=1.245；95%CI：1.063-1.459；p=0.007）。在亚组分析中，这一发现主要局限于男性（OR=1.311）、非高血压参与者（OR=1.443）、糖尿病患者（OR=1.380）和年龄较大（60≤年龄<80）的参与者（OR=1.349）。在调整潜在混杂因素引起的偏倚后，倾向评分匹配分析支持这一结果（OR=1.216；95%CI：1.011-1.462；p=0.038）。
在这项研究中，低剂量阿司匹林用于一级预防与自我报告肾结石之间存在显著关联，主要见于男性、无高血压参与者、糖尿病患者或老年人。未来需要进一步的研究来阐明这些发现的机制。
