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长期存在的水凝胶视网膜植入物导致眼眶肿物巨大。

Large orbital masses due to longstanding hydrogel retinal explants.

作者信息

Mas-Castells Maria, Verity David H, Rose Geoffrey E

机构信息

Orbital Clinic, Moorfields Eye Hospital, London, EC1V 2PD, UK.

出版信息

Eye (Lond). 2024 Mar;38(4):806-808. doi: 10.1038/s41433-023-02783-7. Epub 2023 Oct 14.

Abstract

AIM

To describe the features of orbital masses occurring as a late complication of hydrogel retinal explants.

PATIENTS AND METHODS

Retrospective review of patients presenting with orbital masses at decades after retinal surgery.

RESULTS

Two patients with huge orbital masses are described, their presenting 25 and 28 years after retinal detachment repair with expansile hydrogel explants. In one case, the preoperative diagnosis was pleomorphic adenoma, and the other-with extreme distortion of the globe-was considered to be lymphoma or chronic inflammation arising around prior retinal explants. At orbitotomy, the masses were found to be grossly expanded hydrogel explants that were removed piecemeal from their fibrous capsules. Histopathology showed very mild inflammation with occasional multinucleate giant cells and patchy capsular calcification, and an eosinophilic amorphous material staining strongly with Alcian-blue. Surgery was uncomplicated and both orbits healed with marked functional improvement.

CONCLUSION

Expansile hydrogel retinal explants were largely used in the 1980s and can present, often decades after the retinal surgery, with impaired orbital functions due to large parabulbar masses. The hydrophilic material appears to expand very slowly over decades, leading to gross distortion of neighbouring structures and a tumour-like mass.

摘要

目的

描述作为水凝胶视网膜植入物晚期并发症出现的眼眶肿物的特征。

患者与方法

对视网膜手术后数十年出现眼眶肿物的患者进行回顾性研究。

结果

描述了两名患有巨大眼眶肿物的患者,他们在使用膨胀性水凝胶植入物修复视网膜脱离后25年和28年出现症状。一例术前诊断为多形性腺瘤,另一例眼球严重变形,被认为是先前视网膜植入物周围发生的淋巴瘤或慢性炎症。在眼眶切开术中,发现肿物为明显膨胀的水凝胶植入物,从其纤维包膜中逐块取出。组织病理学显示有非常轻微的炎症,偶见多核巨细胞和散在的包膜钙化,以及一种用阿尔辛蓝染色呈强阳性的嗜酸性无定形物质。手术过程顺利,两个眼眶均愈合,功能有明显改善。

结论

膨胀性水凝胶视网膜植入物在20世纪80年代广泛使用,常在视网膜手术后数十年出现,因球后巨大肿物导致眼眶功能受损。这种亲水性材料在数十年间似乎非常缓慢地膨胀,导致邻近结构严重变形并形成肿瘤样肿物。

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本文引用的文献

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Orbital and Sinonasal Complications of Hydrogel Scleral Buckle: A Case Report.水凝胶巩膜扣带的眼眶和鼻腔鼻窦并发症:一例报告。
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Complications Assoicated with MIRAgel for Treatment of Retinal Detachment.与MIRAgel治疗视网膜脱离相关的并发症
Semin Ophthalmol. 2018;33(1):89-94. doi: 10.1080/08820538.2017.1353822. Epub 2017 Nov 16.
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Good Ideas Gone Bad: The MIRAgel Saga.好主意变坏事:MIRAgel传奇
Ophthalmology. 2016 Jan;123(1):5-6. doi: 10.1016/j.ophtha.2015.09.038.
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Ophthalmology. 2016 Jan;123(1):32-8. doi: 10.1016/j.ophtha.2015.08.018. Epub 2015 Sep 18.
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Globe Loss From Intraocular Invasion of MIRAgel Scleral Buckle Components.MIRAgel巩膜扣带组件眼内侵袭导致的眼球缺失
Ophthalmic Plast Reconstr Surg. 2016 Sep-Oct;32(5):329-32. doi: 10.1097/IOP.0000000000000527.
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Hydrogel explant extrusion masquerading as a malignant eyelid lesion.水凝胶植入物挤出,伪装为恶性眼睑病变。
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