Baenas Nieves, Vega-García Angélica, Manjarrez-Marmolejo Joaquín, Moreno Diego A, Feria-Romero Iris A
Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Espinardo, 30100 Murcia, Spain.
Neurological Diseases Medical Research Unit, National Medical Center "Siglo XXI", IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06720 Mexico City, Mexico.
Biomed Pharmacother. 2023 Dec;168:115720. doi: 10.1016/j.biopha.2023.115720. Epub 2023 Oct 13.
The aggressive and incurable diffuse gliomas constitute 80% of malignant brain tumors, and patients succumb to recurrent surgeries and drug resistance. Epidemiological research indicates that substantial consumption of fruits and vegetables diminishes the risk of developing this tumor type. Broccoli consumption has shown beneficial effects in both cancer and neurodegenerative diseases. These effects are partially attributed to the isothiocyanate sulforaphane (SFN), which can regulate the Keap1/Nrf2/ARE signaling pathway, stimulate detoxifying enzymes, and activate cellular antioxidant defense processes. This study employs a C6 rat glioma model to assess the chemoprotective potential of aqueous extracts from broccoli seeds, sprouts, and inflorescences, all rich in SFN, and pure SFN as positive control. The findings reveal that administering a dose of 100 mg/kg of broccoli sprout aqueous extract and 0.1 mg/kg of SFN to animals for 30 days before introducing 1 × 10 cells effectively halts tumor growth and progression. This study underscores the significance of exploring foods abundant in bioactive compounds, such as derivatives of broccoli, for potential preventive integration into daily diets. Using broccoli sprouts as a natural defense against cancer development might seem idealistic, yet this investigation establishes that administering this extract proves to be a valuable approach in designing strategies for glioma prevention. Although the findings stem from a rat glioma model, they offer promising insights for subsequent preclinical and clinical research endeavors.
侵袭性且无法治愈的弥漫性胶质瘤占恶性脑肿瘤的80%，患者往往因反复手术和耐药性而死亡。流行病学研究表明，大量食用水果和蔬菜可降低患这种肿瘤类型的风险。食用西兰花已显示出对癌症和神经退行性疾病均有有益影响。这些影响部分归因于异硫氰酸酯萝卜硫素（SFN），它可以调节Keap1/Nrf2/ARE信号通路，刺激解毒酶，并激活细胞抗氧化防御过程。本研究采用C6大鼠胶质瘤模型，以评估富含SFN的西兰花种子、芽苗和花序的水提取物以及纯SFN作为阳性对照的化学保护潜力。研究结果表明，在接种1×10个细胞前30天，给动物施用100mg/kg的西兰花芽苗水提取物和0.1mg/kg的SFN，可有效阻止肿瘤生长和进展。本研究强调了探索富含生物活性化合物的食物（如西兰花衍生物）的重要性，以便将其潜在的预防作用纳入日常饮食。将西兰花芽苗用作预防癌症发展的天然防御手段可能看似理想主义，但这项研究表明，施用这种提取物被证明是设计胶质瘤预防策略的一种有价值的方法。尽管研究结果来自大鼠胶质瘤模型，但它们为后续的临床前和临床研究努力提供了有希望的见解。
