Department of Environmental Science, Aarhus University, Denmark.
Department of Environmental Science, Aarhus University, Denmark.
Chemosphere. 2023 Dec;345:140451. doi: 10.1016/j.chemosphere.2023.140451. Epub 2023 Oct 13.
Indoor dust is a sink of hundreds of organic chemicals, and humans may potentially be exposed to these via indoor activities. This study investigated potentially harmful semi-volatile organic contaminants in indoor dust from Danish kindergartens using suspect and non-target screening on gas chromatography (GC)-Orbitrap, supported by target analyses using GC-low resolution mass spectrometry (LRMS). A suspect list of 41 chemicals with one or more toxicological endpoints, i.e. endocrine disruption, carcinogenicity, neurotoxicity and allergenicity, known or suspected to be present in indoor dust, was established including phthalate and non-phthalate plasticizers, flame retardants, bisphenols, biocides, UV filters and other plastic additives. Of these, 29 contaminants were detected in the indoor dust samples, also including several compounds that had been banned or restricted for years. In addition, 22 chemicals were tentatively identified via non-target screening. Several chemicals have not previously been detected in Danish indoor dust. Most of the detected chemicals are known to be potentially harmful for human health while hazard assessment of the remaining compounds indicated limited risks to human. However, children were not specifically considered in this hazard assessment.
室内灰尘是数百种有机化学物质的汇集体，人类可能会通过室内活动而接触到这些化学物质。本研究使用气相色谱（GC）-轨道阱进行可疑物和非靶向筛查，并结合使用 GC-低分辨质谱（LRMS）进行目标分析，调查了丹麦幼儿园室内灰尘中潜在有害的半挥发性有机污染物。可疑列表中包含了 41 种化学物质，其中有一个或多个毒理学终点，即内分泌干扰、致癌性、神经毒性和致敏性，已知或怀疑这些化学物质存在于室内灰尘中，包括邻苯二甲酸酯和非邻苯二甲酸酯增塑剂、阻燃剂、双酚、杀生剂、紫外线过滤器和其他塑料添加剂。其中，29 种污染物在室内灰尘样本中被检测到，其中还包括一些已被禁止或限制多年的化合物。此外，通过非靶向筛查还暂定鉴定出了 22 种化学物质。一些化学物质以前未在丹麦室内灰尘中检测到。大多数已检测到的化学物质已知对人类健康具有潜在危害，而对其余化合物的危害评估表明对人类的风险有限。然而，在这项危害评估中并未特别考虑儿童。
