[化疗后发生肿瘤溶解综合征的腹部伯基特淋巴瘤]
[Abdominal Burkitt's lymphoma developing the tumor lysis syndrome following chemotherapy].
作者信息
Okabe K, Toki H, Kimura Y, Fujii M, Kaneko H, Moriwaki S
出版信息
Gan No Rinsho. 1986 Oct;32(12):1599-603.
A 16-year-old girl was referred to our hospital complaining of a huge abdominal mass and ascites. Cells from the ascites were morphologically compatible with Burkitt's cells. These cells had surface immunoglobulin (gamma and kappa chain) and were positive for B-cell monoclonal antibody (L21, 24). Small numbers of the same cells were present in the bone marrow. Soon after the beginning of chemotherapy, oliguria, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia caused by "tumor lysis" developed. Peritoneal dialysis was not effective, and the patient died of acute renal failure. Autopsy revealed no tumor cells in her body.
一名16岁女孩因腹部巨大肿块和腹水被转诊至我院。腹水中的细胞在形态上与伯基特细胞相符。这些细胞具有表面免疫球蛋白（γ和κ链），并且对B细胞单克隆抗体（L21、24）呈阳性。骨髓中也存在少量相同的细胞。化疗开始后不久，出现了由“肿瘤溶解”引起的少尿、高尿酸血症、高钾血症、高磷血症和低钙血症。腹膜透析无效，患者死于急性肾衰竭。尸检显示其体内无肿瘤细胞。
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