Prados-Carmona Alvaro, Prados-Carmona Juan José, Ruiz-Villaverde Ricardo, Navarro-Triviño Francisco José
Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.
Hospital Universitario Reina Sofía, Córdoba, Spain.
J Dtsch Dermatol Ges. 2023 Dec;21(12):1447-1454. doi: 10.1111/ddg.15186. Epub 2023 Oct 15.
To date, the clinical appearance and histological features of multiple minute digitate hyperkeratosis have been well characterized. However, there is no consensus on its treatment. After a comprehensive search of the databases MEDLINE, EMBASE, Web of Science, and the Cochrane Library and Database of Systematic Reviews, we have summarized the available clinical evidence regarding the therapeutic approaches already reported for this entity since its first description in 1967. Additional publications were identified within the references of retrieved papers. Sixty-five articles have been revised, resulting in a total of 73 compatible cases. The histopathological features and different classifications used through history have also been considered, updating and completing the available knowledge. Ultimately, we propose topical treatment with 5 % 5-fluorouracil formulated with 10 % salicylic acid as a potential treatment that has been used successfully in a 51-year-old woman at our facility. Further research in form of prospective or comparative studies is encouraged for a better conceptualization of the therapeutics of this disease.
迄今为止，多发性微小指状角化过度的临床表现和组织学特征已得到充分描述。然而，对于其治疗方法尚无共识。在全面检索MEDLINE、EMBASE、科学网以及Cochrane图书馆和系统评价数据库后，我们总结了自1967年首次描述该病症以来已报道的治疗方法的现有临床证据。在检索到的论文参考文献中确定了其他出版物。已审阅65篇文章，共涉及73例符合条件的病例。还考虑了其组织病理学特征以及历年来使用的不同分类方法，更新并完善了现有知识。最终，我们提出使用含10%水杨酸的5% 5-氟尿嘧啶进行局部治疗，这是一种已在我们机构成功应用于一名51岁女性的潜在治疗方法。鼓励开展前瞻性或对比性研究，以更好地明确该疾病的治疗方法。
