Gour Vivek K, Yahya Shaikh, Shahar Yar Mohammad
Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Arch Pharm (Weinheim). 2024 Jan;357(1):e2300328. doi: 10.1002/ardp.202300328. Epub 2023 Oct 15.
Oxadiazoles and thiadiazoles are malleable heterocycles that have recently generated major interest in the field of medicinal chemistry. Compounds based on these moieties have versatile biological applications such as anticonvulsant, anticancer, antidiabetic, and antioxidant agents. Due to the versatile nature and stability of the oxadiazole and thiadiazole nucleus, medicinal chemists have changed the structural elements of the ring in numerous ways. These compounds have shown significant anticonvulsant effects, demonstrating their potential in the management of epileptic disorders. In this review, we have covered numerous biological pathways and in silico targeted proteins of oxadiazole and thiadiazole derivatives for treating various biological disorders. The data compiled in this article will be helpful for researchers, research scientists, and research chemists who work in the field of drug discovery and drug development.
恶二唑和噻二唑是具有可塑性的杂环化合物，最近在药物化学领域引起了广泛关注。基于这些基团的化合物具有多种生物学应用，如抗惊厥、抗癌、抗糖尿病和抗氧化剂。由于恶二唑和噻二唑核的多功能性和稳定性，药物化学家以多种方式改变了环的结构元素。这些化合物已显示出显著的抗惊厥作用，证明了它们在治疗癫痫疾病方面的潜力。在这篇综述中，我们涵盖了恶二唑和噻二唑衍生物用于治疗各种生物紊乱的众多生物学途径和计算机模拟靶向蛋白。本文汇编的数据将有助于从事药物发现和药物开发领域的研究人员、科研人员和化学研究人员。
