Heser Kathrin, Kleineidam Luca, Wagner Michael, Luppa Melanie, Löbner Margrit, Wiese Birgitt, Oey Anke, König Hans-Helmut, Brettschneider Christian, van der Leeden Carolin, van den Bussche Hendrik, Fuchs Angela, Pentzek Michael, Weyerer Siegfried, Werle Jochen, Bickel Horst, Scherer Martin, Maier Wolfgang, Ramirez Alfredo, Riedel-Heller Steffi G
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, North Rhine-Westphalia, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, North Rhine-Westphalia, Germany.
J Alzheimers Dis. 2023;96(2):579-589. doi: 10.3233/JAD-230410.
Subjective memory complaints and family history of dementia are possibly intertwined risk factors for the own subsequent dementia risk and Alzheimer's disease. However, their interaction has rarely been studied.
To study the association between subjective memory complaints and family history of dementia with regard to the own subsequent risk of dementia.
Cross-sectional and longitudinal analyses over a follow-up period of up to 13 years were conducted in a population sample of participants without dementia at baseline (n = 3,256, mean age = 79.62 years), using group comparisons and Cox proportional hazards models.
Cross-sectionally, participants with subjective memory complaints were significantly more likely to report family history of dementia. Longitudinally, family history of dementia (FH) was significantly associated with subsequent dementia in the subjective memory complaints (SMC) group, but not in those without SMC. A relative excess risk due to interaction analysis confirmed a significant FHxSMC-interaction.
Family history of dementia was a predictor of incident dementia in those with SMC, which can serve as an additional, clinically relevant criterion to gauge the risk of dementia in older-aged subjects with SMC with and without objective cognitive impairment.
主观记忆主诉和痴呆家族史可能是自身后续患痴呆症风险和阿尔茨海默病的相互交织的风险因素。然而，它们之间的相互作用很少被研究。
研究主观记忆主诉和痴呆家族史与自身后续患痴呆症风险之间的关联。
在基线时无痴呆症的参与者群体样本（n = 3256，平均年龄 = 79.62岁）中进行了长达13年随访期的横断面和纵向分析，采用组间比较和Cox比例风险模型。
横断面分析中，有主观记忆主诉的参与者报告痴呆家族史的可能性显著更高。纵向分析中，痴呆家族史（FH）在主观记忆主诉（SMC）组中与后续痴呆症显著相关，但在无SMC的组中则不然。交互作用分析得出的相对超额风险证实了显著的FHxSMC交互作用。
痴呆家族史是有SMC者发生痴呆症的一个预测因素，这可作为一个额外的、具有临床相关性的标准，用于评估有和无客观认知障碍的有SMC的老年受试者患痴呆症的风险。
