Li Anqi, Du Jing, Cai Yue, Chen Xuhui, Sun Kun, Guo Tengfei
Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China.
J Alzheimers Dis. 2023;96(2):643-655. doi: 10.3233/JAD-230446.
Body mass index (BMI) changes may be related to Alzheimer's disease (AD) alterations, but it is unclear how the apolipoprotein E ɛ4 (APOE ɛ4) allele affects their association.
To explore the association of BMI changes with AD pathologies in APOE ɛ4 carriers and non-carriers.
In 862 non-demented ADNI participants with≥2 BMI measurements, we investigated the relationships between BMI slopes and longitudinal changes in amyloid-β (Aβ) accumulation, neurodegeneration and cognition, and follow-up tau deposition in different Aβ and APOE ɛ4 statuses.
In Aβ+ APOE ɛ4 non-carriers, faster BMI declines were associated with faster rates of Aβ accumulation (standardized β (βstd) = -0.29, p = 0.001), AD meta regions of interest (metaROI) hypometabolism (βstd = 0.23, p = 0.026), memory declines (βstd = 0.17, p = 0.029), executive function declines (βstd = 0.19, p = 0.011), and marginally faster Temporal-metaROI cortical thinning (βstd = 0.15, p = 0.067) and higher follow-up Temporal-metaROI tau deposition (βstd = -0.17, p = 0.059). Among Aβ- individuals, faster BMI decreases were related to faster Aβ accumulation (βstd = -0.25, p = 0.023) in APOE ɛ4 carriers, whereas predicted faster declines in memory and executive function in both APOE ɛ4 carriers (βstd = 0.25, p = 0.008; βstd = 0.32, p = 0.001) and APOE ɛ4 non-carriers (βstd = 0.11, p = 0.030; βstd = 0.12, p = 0.026).
This study highlights the significance of tracking BMI data in older adults by providing novel insights into how body weight fluctuations and APOE ɛ4 interact with AD pathology and cognitive decline.
体重指数（BMI）变化可能与阿尔茨海默病（AD）改变有关，但尚不清楚载脂蛋白Eε4（APOEε4）等位基因如何影响它们之间的关联。
探讨BMI变化与APOEε4携带者和非携带者AD病理之间的关联。
在862名有≥2次BMI测量值的非痴呆ADNI参与者中，我们研究了BMI斜率与淀粉样β蛋白（Aβ）积累、神经退行性变和认知的纵向变化以及不同Aβ和APOEε4状态下随访tau沉积之间的关系。
在Aβ阳性APOEε4非携带者中，BMI下降越快与Aβ积累速度越快（标准化β（βstd）=-0.29，p=0.001）、AD感兴趣元区域（metaROI）代谢减退（βstd=0.23，p=0.026）、记忆力下降（βstd=0.17，p=0.029）、执行功能下降（βstd=0.19，p=0.011）以及颞叶metaROI皮质变薄略快（βstd=0.15，p=0.067）和随访时颞叶metaROI tau沉积更高（βstd=-0.17，p=0.059）相关。在Aβ阴性个体中，BMI下降越快与APOEε4携带者中Aβ积累越快（βstd=-0.25，p=0.023）相关，而在APOEε4携带者（βstd=0.25，p=0.008；βstd=0.32，p=0.001）和APOEε4非携带者（βstd=0.11，p=0.030；βstd=着执行功能下降越快（βstd=0.12，p=0.026）。
本研究通过提供关于体重波动和APOEε4如何与AD病理及认知衰退相互作用的新见解，突出了在老年人中跟踪BMI数据的重要性。
