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米希希。多糖通过抑制铁死亡和 PI3K/AKT 通路介导的细胞凋亡以及调节色氨酸代谢来改善糖尿病肾病小鼠模型。

Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism.

机构信息

Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.

Graduate School of Chengde Medical University, Chengde, China.

出版信息

J Diabetes Res. 2023 Oct 5;2023:9164883. doi: 10.1155/2023/9164883. eCollection 2023.

DOI:10.1155/2023/9164883
PMID:37840577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10569897/
Abstract

Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers various renal cell dysfunctions, eventually leading to progressive kidney failure. Michx. is a traditional Chinese herbal medicine. Many studies have confirmed its antioxidative, anti-inflammatory, and renoprotective effects. However, the effects and mechanisms of Michx. polysaccharide (RLP) in DN remain unclear. In this study, a DN mouse model was established to investigate the therapeutic effect of RLP on DN mice. Then, nontargeted metabolomics was used to analyze the potential mechanism of RLP in the treatment of DN. Finally, the effects of RLP on ferroptosis and the PI3K/AKT pathway were investigated. The results demonstrated that RLP effectively alleviated renal injury and reduced inflammation and oxidative stress in the kidney. In addition, nontargeted metabolomic analysis indicated that RLP could modulate riboflavin metabolism and tryptophan metabolism in DN mice. Notably, ferroptosis and PI3K/AKT pathway-mediated apoptosis in the kidney were also ameliorated following RLP treatment. In conclusion, this study confirmed that RLP had a significant therapeutic effect on DN mice. Furthermore, RLP treatment modulated tryptophan metabolism and inhibited ferroptosis and PI3K/AKT pathway-mediated apoptosis in the kidney.

摘要

糖尿病肾病（DN）是一种代谢性疾病，其中慢性高血糖会引发各种肾细胞功能障碍，最终导致进行性肾衰竭。 Michx. 是一种传统的中草药。许多研究证实了它的抗氧化、抗炎和肾保护作用。然而， Michx. 多糖（RLP）在 DN 中的作用和机制尚不清楚。在这项研究中，建立了一个 DN 小鼠模型，以研究 RLP 对 DN 小鼠的治疗效果。然后，采用非靶向代谢组学分析 RLP 治疗 DN 的潜在机制。最后，研究了 RLP 对铁死亡和 PI3K/AKT 通路的影响。结果表明，RLP 能有效缓解肾损伤，减轻肾脏的炎症和氧化应激。此外，非靶向代谢组学分析表明，RLP 能调节 DN 小鼠的核黄素代谢和色氨酸代谢。值得注意的是，RLP 处理还能改善肾脏中的铁死亡和 PI3K/AKT 通路介导的细胞凋亡。总之，本研究证实 RLP 对 DN 小鼠有显著的治疗作用。此外，RLP 治疗能调节色氨酸代谢，抑制铁死亡和 PI3K/AKT 通路介导的细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/f27aa002c629/JDR2023-9164883.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/4626f790da24/JDR2023-9164883.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/f27aa002c629/JDR2023-9164883.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/4626f790da24/JDR2023-9164883.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/241d104d299f/JDR2023-9164883.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/18c62810cf85/JDR2023-9164883.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/4bc4989ba59a/JDR2023-9164883.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/06f18fcfc749/JDR2023-9164883.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/158fb4d7e293/JDR2023-9164883.006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6558/10569897/f27aa002c629/JDR2023-9164883.008.jpg

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