Davidson Trent, Boardman Jason D, Hunter Lori M
University of Colorado at Boulder.
J Rural Soc Sci. 2022;37(1).
This paper contributes to research on health disparities among rural and urban residents by considering differences in the magnitude of genetic associations for physical health, mental health, and health behaviors across the two settings. Previous research has shown reduced genetic associations in rural compared to urban settings but none have utilized current genome-wide polygenic scores and none have focused on older adults. Using a sample of 14,994 adults from the 1992 to 2016 waves of the Health and Retirement Study our results suggest genetic associations for BMI (p<.018) and heart conditions (p < .023) are significantly reduced in rural compared to urban settings and we find weak evidence in support of this association for depression (p. < .065) and no evidence for smoking (p < 461). In sum, the weaker genetic associations in rural areas highlights the centrality of the social, economic, and built environment as a determinant of disparities.
本文通过考虑城乡居民在身体健康、心理健康和健康行为方面基因关联程度的差异，为城乡居民健康差异研究做出了贡献。先前的研究表明，与城市环境相比，农村地区的基因关联有所减少，但均未使用当前的全基因组多基因评分，也没有关注老年人。我们使用了来自1992年至2016年健康与退休研究各波次的14994名成年人样本，结果表明，与城市环境相比，农村地区体重指数（p<0.018）和心脏病（p<0.023）的基因关联显著降低，我们发现有微弱证据支持抑郁症的这种关联（p<0.065），而吸烟方面没有证据（p<461）。总之，农村地区较弱的基因关联凸显了社会、经济和建筑环境作为差异决定因素的核心地位。
