一名患有李-弗劳梅尼综合征的患者，继发于成熟卵巢囊性畸胎瘤的继发性体细胞性胶质母细胞瘤。
Secondary somatic glioblastoma arising from a mature ovarian cystic teratoma in a patient with underlying Li-Fraumeni syndrome.
作者信息
Bussies Parker L, Chau Danielle B, Hunt Jonathan T, Policarpio-Nicolas Maria Luisa C, Friedman Cameron, McKenney Jesse K, Yeaney Gabrielle A, Peereboom David M, Beffa Lindsey
机构信息
Women's Health Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH, United States.
出版信息
Gynecol Oncol Rep. 2023 Sep 26;49:101279. doi: 10.1016/j.gore.2023.101279. eCollection 2023 Oct.
•First report of a secondary somatic glioblastoma arising from MCT-MT in a patient with underlying Li-Fraumeni syndrome.•The rarity of glioblastoma arising from MCT-MT warrants investigation for underlying genetic predisposition.•Glioblastomas arising from MCT-MT appear to exhibit wild type gene status.•Advanced-stage glioblastoma arising from MCT-MT exhibits aggressive behavior and requires adjuvant therapy.•Optimal adjuvant therapy regimen for glioblastoma arising from MCT-MT remains unknown.
•首例源于伴有潜在李-弗劳梅尼综合征患者的黏液样软骨肉瘤-间叶型软骨肉瘤的继发性体细胞性胶质母细胞瘤报告。
•源于黏液样软骨肉瘤-间叶型软骨肉瘤的胶质母细胞瘤的罕见性值得对潜在的遗传易感性进行研究。
•源于黏液样软骨肉瘤-间叶型软骨肉瘤的胶质母细胞瘤似乎表现出野生型基因状态。
•源于黏液样软骨肉瘤-间叶型软骨肉瘤的晚期胶质母细胞瘤表现出侵袭性，需要辅助治疗。
•源于黏液样软骨肉瘤-间叶型软骨肉瘤的胶质母细胞瘤的最佳辅助治疗方案尚不清楚。
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