和三萜的区域特异性酶糖化及其生物活性。
Regio-specific enzymatic glucosylation of triterpenoids from and their biological activities.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
出版信息
Org Biomol Chem. 2023 Nov 1;21(42):8467-8470. doi: 10.1039/d3ob01286g.
The bacterial glycosyltransferase YjiC1 was used to glycosylate triterpenoids from the medicinal fungus . Eleven new compounds were obtained from enzymatic reactions. Glucosylation could increase the inhibitory activities against COX-2, and improve the anti-inflammatory activities of ergostanes on acute lung injury mice, especially (25)-antcin C 7--D-glucoside.
细菌糖基转移酶 YjiC1 被用于糖基化药用真菌中的三萜类化合物。从酶反应中获得了 11 种新化合物。葡萄糖苷化可以提高环氧合酶-2 的抑制活性，并提高麦角甾烷对急性肺损伤小鼠的抗炎活性，特别是(25)-antcin C 7--D-葡萄糖苷。
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