长链非编码 RNA/环状 RNA-miRNA-mRNA 轴在动脉粥样硬化炎症中的作用：研究进展。

LncRNA/CircRNA-miRNA-mRNA Axis in Atherosclerotic Inflammation: Research Progress.

机构信息

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Traditional Chinese Medicine Department, Ganzhou People's Hospital, Ganzhou, China.

出版信息

Curr Pharm Biotechnol. 2024;25(8):1021-1040. doi: 10.2174/0113892010267577231005102901.

DOI:10.2174/0113892010267577231005102901

PMID:37842894

Abstract

Atherosclerosis is characterized by chronic inflammation of the arterial wall. However, the exact mechanism underlying atherosclerosis-related inflammation has not been fully elucidated. To gain insight into the mechanisms underlying the inflammatory process that leads to atherosclerosis, there is need to identify novel molecular markers. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-protein-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have gained prominence in recent years. LncRNAs/circRNAs act as competing endogenous RNAs (ceRNAs) that bind to miRNAs microRNA response elements (MREs), thereby inhibiting the silencing of miRNA target mRNAs. Inflammatory mediators and inflammatory signaling pathways are closely regulated by ceRNA regulatory networks in atherosclerosis. In this review, we discuss the role of LncRNA/CircRNA-miRNA-mRNA axis in atherosclerotic inflammation and how it can be targeted for early clinical detection and treatment.

摘要

动脉粥样硬化的特征是动脉壁的慢性炎症。然而，动脉粥样硬化相关炎症的确切机制尚未完全阐明。为了深入了解导致动脉粥样硬化的炎症过程的机制，需要识别新的分子标记物。非编码 RNA（ncRNA），包括 microRNAs（miRNAs）、长非蛋白编码 RNA（lncRNA）和环状 RNA（circRNA），近年来受到了广泛关注。lncRNA/circRNA 作为竞争性内源 RNA（ceRNA），可以与 miRNAs 结合 miRNA 反应元件（MRE），从而抑制 miRNA 靶 mRNA 的沉默。在动脉粥样硬化中，炎症介质和炎症信号通路受到 ceRNA 调控网络的密切调控。在这篇综述中，我们讨论了 LncRNA/CircRNA-miRNA-mRNA 轴在动脉粥样硬化炎症中的作用，以及如何针对其进行早期临床检测和治疗。