Henrich W L, Walker B R, Handelman W A, Erickson A L, Arnold P E, Schrier R W
Kidney Int. 1986 Oct;30(4):503-8. doi: 10.1038/ki.1986.214.
The effects of intravenous (i.v.) and intracarotid (IC) angiotensin II (AII) infusion on systemic and renal hemodynamics, renal water excretion, and plasma antidiuretic hormone (ADH) levels were examined in six conscious dogs under water loaded and hydropenic conditions. In the first group of seven studies, AII in a mean dose of 12.7 ng/kg/min was administered i.v. to water loaded dogs. The infusion induced a significant increase in mean arterial pressure (MAP, 99 to 118 mm Hg, P less than 0.001), and significant reductions in both glomerular filtration rate (GFR, 67 to 57 ml/min, P less than 0.05) and para-aminohippurate clearance (CPAH, 280 to 212 ml/min, P less than 0.005) occurred. Despite this decrement in renal hemodynamics, urine remained maximally dilute (Uosm, 58 to 61 mOsm/kg H2O, NS). Furthermore, plasma ADH was suppressed maximally after water load and did not increase after i.v. AII infusion. The IC infusion of AII (mean dose 5.8 ng/kg/min) produced similar changes in hemodynamics; plasma ADH remained undetectable. When AII was administered i.v. to hydropenic animals (mean dose 8.3 ng/kg/min), MAP again increased (86 to 111 mm Hg, P less than 0.001) as GFR (81.3 to 68.6 ml/min, NS) and CPAH (291 to 223 ml/min, P less than 0.05) declined modestly. In these animals, Uosm decreased significantly (1429 to 1114 mOsm/kg H2O, P less than 0.005) and plasma ADH did not change significantly (1.66 to 1.88 pg/ml, NS). When IC AII (4 ng/kg/min) was repeated in hydropenic dogs pretreated with indomethacin, neither Usom (1787 to 1664 mOsm/kg H2O, NS) nor plasma ADH were altered.(ABSTRACT TRUNCATED AT 250 WORDS)
在水负荷和禁水条件下，对6只清醒犬静脉内（i.v.）和颈内（IC）输注血管紧张素II（AII）对全身和肾脏血流动力学、肾脏水排泄及血浆抗利尿激素（ADH）水平的影响进行了研究。在第一组7项研究中，以平均剂量12.7 ng/kg/min的AII静脉内给予水负荷犬。输注导致平均动脉压显著升高（MAP，从99至118 mmHg，P<0.001），同时肾小球滤过率（GFR，从67至57 ml/min，P<0.05）和对氨基马尿酸清除率（CPAH，从280至212 ml/min，P<0.005）均显著降低。尽管肾脏血流动力学出现这种下降，但尿液仍保持最大稀释度（尿渗透压，Uosm，从58至61 mOsm/kg H2O，无显著差异）。此外，水负荷后血浆ADH被最大程度抑制，静脉内输注AII后未升高。颈内输注AII（平均剂量5.8 ng/kg/min）产生了类似血流动力学变化；血浆ADH仍未检测到。当静脉内给予禁水动物AII（平均剂量8.3 ng/kg/min）时，MAP再次升高（从86至111 mmHg，P<0.001），同时GFR（从81.3至68.6 ml/min，无显著差异）和CPAH（从291至223 ml/min，P<0.05）适度下降。在这些动物中，Uosm显著降低（从1429至1114 mOsm/kg H2O，P<0.005），而血浆ADH无显著变化（从1.66至1.88 pg/ml，无显著差异）。当对用吲哚美辛预处理的禁水犬重复颈内给予AII（4 ng/kg/min）时，Uosm（从1787至1664 mOsm/kg H2O，无显著差异）和血浆ADH均未改变。（摘要截短至250字）
