Yazicioglu Murat Burc, Eraldemir Fatma Ceyla, Gunes Abdullah, Turgut Hamdi Taner, Ciftci Ali
Department of General Surgery, Kocaeli Derince Training and Research Hospital, University of Health Science, Kocaeli, Turkey.
Department of Biochemistry, School of Medicine, University of Kocaeli, Kocaeli, Turkey.
J Minim Access Surg. 2023 Oct-Dec;19(4):529-534. doi: 10.4103/jmas.jmas_345_22.
Ischaemic preconditioning is the most effective method for the prevention of ischaemic-reperfusion injury; however, no study has examined the question of the ideal time for ischaemic preconditioning.
The patients were divided into five groups, each group including of 20 patients. The precondition was applied as 1, 5, 10 and 15 min in Groups I, II, III and IV and Group V was the control group. Repeated blood samples were taken to measure the total antioxidant status (TAS), total oxidant status and oxidative stress index (OSI) values, just before insufflation, at the end of the operation and at 6 and 24 h of the post-operative period.
A significant difference was observed between the TAS values at the end of the operation and at the sixth post-operative time of the four groups (P = 0.001, 0.000, 0.001, 0.019 and 0.033, respectively). Furthermore, a significant difference was observed between TAS values at the post-operative 24 h of Group III and Group V, and also a significant difference was observed between the OSI values at the post-operative 6 h of Groups III and V.
The low OSI and TAS values may interpret as a low degree of oxidative damage. The OSI values at the post-operative 6 h of Groups I and II were lower than those of other groups. We accept this result as low oxidative damage.
缺血预处理是预防缺血再灌注损伤最有效的方法；然而，尚无研究探讨缺血预处理的理想时间问题。
将患者分为五组，每组20例。第一、二、三、四组分别进行1、5、10和15分钟的预处理，第五组为对照组。在气腹前、手术结束时以及术后6小时和24小时重复采集血样，以测量总抗氧化状态（TAS）、总氧化状态和氧化应激指数（OSI）值。
四组手术结束时和术后第六小时的TAS值之间存在显著差异（分别为P = 0.001、0.000、0.001、0.019和0.033）。此外，第三组和第五组术后24小时的TAS值之间存在显著差异，第三组和第五组术后6小时的OSI值之间也存在显著差异。
低OSI和TAS值可能意味着氧化损伤程度较低。第一组和第二组术后6小时的OSI值低于其他组。我们认为这一结果表明氧化损伤较低。
