[Effect of hypokinesia on the intensity of gluconeogenesis in the rat kidney cortex].

The rate of gluconeogenesis was measured in the cortical layer of kidneys of 95 white rats on hypokinesia days 1, 3, 7, 15, 30 and 60. At early stages of hypokinesia the rate of glucose formation from aspartic, glutamic, pyruvic, alpha-ketoglutaric acids and glycerol increased, specifically on hypokinesia day 3. The rate of glucose formation from the amino acids on hypokinesia day 30 was identical to that in the controls. The rate of glucose formation from alpha-ketoglutaric and succinic acids increased and that from pyruvic acid significantly decreased. On hypokinesia day 30 the rate of glucose formation from every substrate used, except for pyruvic acid, increased. The glucose concentration in serum was higher on hypokinesia days 1-7 and lower on hypokinesia days 15-60. The changes in the rate of glucose formation in the kidneys make inexplicable stable hypoglycemia seen at later stages of hypokinesia.