Graduate School of Education, The University of Tokyo, Tokyo, Japan.
Adv Exp Med Biol. 2023;1438:197-202. doi: 10.1007/978-3-031-42003-0_31.
We developed a multidistance and multiwavelength continuous wave NIRS instrument to detect dynamic changes in oxygenated and deoxygenated hemoglobin (oxy- and deoxy-Hb), oxidized cytochrome-c-oxidase (oxCCO) and water of the brain and muscle. We performed measurements of the forehead during resting state and paced breathing and of the forearm during ischemic challenge in human adults. Time series analysis focusing on rhythmic signals over different time scales and different depths of the tissue revealed specific patterns of phase relationships among the signals in each of the measurement. This method can be a promising tool to understand the dynamic interaction among the neurovascular, metabolic and glymphatic system in a wide variety of subject fields.
我们开发了一种多距离和多波长连续波近红外光谱仪，以检测脑和肌肉中氧合和去氧血红蛋白（氧合和去氧 Hb）、氧化细胞色素 c 氧化酶（oxCCO）和水的动态变化。我们在成年人休息状态和有节奏呼吸时对头额进行了测量，在缺血性挑战时对前臂进行了测量。时间序列分析侧重于不同时间尺度和组织不同深度的节奏信号，揭示了每种测量中信号之间相位关系的特定模式。这种方法有望成为理解神经血管、代谢和神经胶质系统在广泛的研究领域中的动态相互作用的工具。
