Danesi R, Del Tacca M, Soldani G
J Pharmacol Methods. 1986 Nov;16(3):251-9. doi: 10.1016/0160-5402(86)90046-x.
A new method is described for the assessment of the early cardiotoxic effects of adriamycin and related drugs on rat electrocardiographic parameters. Evidence is presented that during repeated treatment with adriamycin, no changes occur concerning the PR and RR intervals, QTc, or R- and S-wave voltages, whereas significant changes in the QRS complex, R alpha T and alpha TP intervals, and T-wave voltage are detectable. However, the earliest and most consistent electrocardiogram alteration observed during adriamycin treatment is a progressive, irreversible widening of the S alpha T segment. The S alpha T enlargement becomes significant during the first week of treatment and may be detected in all the tracings at all the times examined. The electrocardiogram changes are accompanied by cardiac histological lesions that gradually increase in severity during the study. These results indicate that the measurement of the S alpha T segment provides a rapid, sensitive, and reliable method for the evaluation of electrocardiogram toxicity induced by adriamycin and related anthracyclines in the rat.
描述了一种评估阿霉素及相关药物对大鼠心电图参数早期心脏毒性作用的新方法。有证据表明，在反复使用阿霉素治疗期间，PR间期、RR间期、QTc或R波及S波电压无变化，而QRS波群、RαT和αTP间期以及T波电压有显著变化。然而，在阿霉素治疗期间观察到的最早且最一致的心电图改变是SαT段进行性、不可逆增宽。SαT增宽在治疗的第一周变得显著，并且在所有检查时间的所有描记图中均可检测到。心电图改变伴有心脏组织学损伤，在研究过程中其严重程度逐渐增加。这些结果表明，SαT段的测量为评估阿霉素及相关蒽环类药物在大鼠中引起的心电图毒性提供了一种快速、灵敏且可靠的方法。
